Jonathan Dubé

TL;DR: It is suggested that microstructural degradation of specific cortical regions compromise SW generation and propagation in older subjects, critically contributing to age-related changes in SW oscillations.

TL;DR: Higher spindle density predicted better performance on verbal learning, visual attention and verbal fluency, whereas spindle frequency and slow wave density or slope predicted fewer cognitive performance variables.

TL;DR: The results indicate that the effects of aging on the sleep–wake activities in mice occur mainly during the dark phase and the electrode location strongly influence the state detection.

TL;DR: It is shown, for the first time, that the switch from fast to slow oscillatory mode during sleep spindles is required for the emergence of specific patterns of connectivity.

TL;DR: The results show that age-related reduction in low-frequency delta activity during both rapid eye movement and nonrapid eye movement sleep was statistically mediated by the thinning of the medial frontal and anterior cingulate cortices, and suggest that, with age, a reduction in cortical integrity within this frontal network mediates the loss of delta power during sleep.