J
Jonathon C. Arnold
Researcher at University of Sydney
Publications - 122
Citations - 4744
Jonathon C. Arnold is an academic researcher from University of Sydney. The author has contributed to research in topics: Cannabidiol & Cannabinoid. The author has an hindex of 35, co-authored 101 publications receiving 3674 citations.
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Adolescent rats find repeated Delta(9)-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure.
Heidi R Quinn,Izuru Matsumoto,Paul D. Callaghan,Leonora E. Long,Jonathon C. Arnold,Nathan Gunasekaran,Murray R. Thompson,Bronwyn Dawson,Paul E. Mallet,Mohammed Abul Kashem,Haruka Matsuda-Matsumoto,Takeshi Iwazaki,Iain S. McGregor +12 more
TL;DR: It is suggested that adolescent rats find repeated Δ9-THC exposure less aversive than adults, but that cannabinoid exposure causes greater lasting memory deficits and hippocampal alterations in adolescent than adult rats.
Journal ArticleDOI
Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Δ9-tetrahydrocannabinol
Aurelie A. Boucher,Aurelie A. Boucher,Jonathon C. Arnold,Liesl Duffy,Peter R. Schofield,Peter R. Schofield,Jacques Micheau,Tim Karl +7 more
TL;DR: Nrg1 HET mice were more sensitive to the acute effects of THC in an array of different behaviours including those that model symptoms of schizophrenia.
Journal ArticleDOI
Stress-Induced Grey Matter Loss Determined by MRI Is Primarily Due to Loss of Dendrites and Their Synapses
Mustafa S. Kassem,Jim Lagopoulos,Timothy Stait-Gardner,William S. Price,Tariq W. Chohan,Jonathon C. Arnold,Sean N. Hatton,Max R. Bennett +7 more
TL;DR: This quantitative study is the first to relate GMV changes in the cortex measured with MRI to volume changes in cellular constituents of the grey matter.
Journal ArticleDOI
Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
Charlotte Klein,Emily A Karanges,Adena S. Spiro,Alexander Wong,Jarrah R. Spencer,Thanh Huynh,Nathan Gunasekaran,Tim Karl,Leonora E. Long,Xu-Feng Huang,Kelly Liu,Jonathon C. Arnold,Iain S. McGregor +12 more
TL;DR: CBD can potentiate the psychoactive and physiological effects of THC in rats, most likely by delaying the metabolism and elimination of THC through an action on the CYP450 enzymes that metabolise both drugs.
Journal ArticleDOI
A behavioural comparison of acute and chronic Δ9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice
Leonora E. Long,Rose Chesworth,Rose Chesworth,Xu-Feng Huang,Iain S. McGregor,Jonathon C. Arnold,Tim Karl,Tim Karl +7 more
TL;DR: First evidence of anxiolytic- and antipsychotic-like effects of chronic but not acute CBD in C57BL/6JArc mice is provided, extending findings from acute studies in other inbred mouse strains and rats.