T
Tim Karl
Researcher at University of Sydney
Publications - 125
Citations - 5135
Tim Karl is an academic researcher from University of Sydney. The author has contributed to research in topics: Neuregulin 1 & Prepulse inhibition. The author has an hindex of 39, co-authored 117 publications receiving 4405 citations. Previous affiliations of Tim Karl include Hannover Medical School & University of New South Wales.
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Journal ArticleDOI
Behavioral phenotyping of mice in pharmacological and toxicological research.
TL;DR: A general approach is designed to describe a general approach, which increases reliability of behavioral screening, and provides an overview on a selection of specific procedures suitable for but not limited to behavioral screening in pharmacology and toxicology.
Journal ArticleDOI
Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity.
Dana Boey,Shu Lin,Tim Karl,Paul A. Baldock,Nicola J. Lee,Ronaldo F. Enriquez,Michelle Couzens,Katy Slack,Robert Dallmann,Amanda Sainsbury,Herbert Herzog +10 more
TL;DR: PYY signalling is important in the regulation of energy balance and glucose homeostasis, possibly via regulation of insulin release, and reduced PYY levels may predispose to the development of obesity, particularly with ageing or under conditions of high-fat feeding.
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Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Δ9-tetrahydrocannabinol
Aurelie A. Boucher,Aurelie A. Boucher,Jonathon C. Arnold,Liesl Duffy,Peter R. Schofield,Peter R. Schofield,Jacques Micheau,Tim Karl +7 more
TL;DR: Nrg1 HET mice were more sensitive to the acute effects of THC in an array of different behaviours including those that model symptoms of schizophrenia.
Journal ArticleDOI
Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease.
Woojin S. Kim,Hongyun Li,Hongyun Li,Kalani Ruberu,Kalani Ruberu,Sharon Chan,Sharon Chan,David A. Elliott,David A. Elliott,David A. Elliott,Jac Kee Low,David Cheng,David Cheng,Tim Karl,Tim Karl,Brett Garner,Brett Garner +16 more
TL;DR: It is shown that ABCA7 loss doubled insoluble Aβ levels and thioflavine-S–positive plaques in the brain and that this may be related to altered phagocyte function.
Journal ArticleDOI
Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
Charlotte Klein,Emily A Karanges,Adena S. Spiro,Alexander Wong,Jarrah R. Spencer,Thanh Huynh,Nathan Gunasekaran,Tim Karl,Leonora E. Long,Xu-Feng Huang,Kelly Liu,Jonathon C. Arnold,Iain S. McGregor +12 more
TL;DR: CBD can potentiate the psychoactive and physiological effects of THC in rats, most likely by delaying the metabolism and elimination of THC through an action on the CYP450 enzymes that metabolise both drugs.