Jong In Yook

TL;DR: In this paper, the authors demonstrate that canonical Wnt signalling engages tumour cell dedifferentiation and tissue-invasive activity through an Axin2-dependent pathway that stabilizes the Snail1 zinc-transcription factor, a key regulator of normal and neoplastic EMT programs.

TL;DR: In this paper, the 3'-end of conserved miRNAs in particular has significant interaction sites in the human-enriched, less conserved 5'-UTR miRNA motifs.

TL;DR: The predicted targets of this new miRNA target class, miBridge, are provided as an efficient way to screen potential targets, especially for nonconserved miRNAs, since the target search space is reduced by an order of magnitude compared with the 3'-UTR alone.

TL;DR: It is demonstrated that Snail displays β-catenin-like canonical motifs that support its GSK3β-dependent phosphorylation, β-TrCP-directed ubiquitination, and proteasomal degradation, which defines a potential mechanism whereby Wnt signaling stabilizes Snail and β-catsin proteins in tandem fashion so as to cooperatively engage transcriptional programs that control an epithelial-mesenchymal transition.

TL;DR: Expression of the essential EMT inducer Snail1 is inhibited by miR-34 through a p53-dependent regulatory pathway.