Jorge H. Limón-Pacheco

TL;DR: Evidence of organ-specific antioxidant responses elicited by environmental pollutants in humans and animal models is reviewed and it is suggested that in complex organisms such as mammals, organs and tissues contain distinct antioxidant systems, and this may form the basis for differential susceptibility to environmental toxic agents.

TL;DR: Brain would be more susceptible to GR inhibition because of the decreased activities of superoxide dismutase (SOD) and catalase reported in this tissue, and significant inhibition of the expression and activity of GR was observed only at the highest concentration used in both organs.

TL;DR: It is indicated that chronic As exposure leads to gender-dependent alterations in dopaminergic markers and spontaneous locomotor activity, and down-regulation of the antioxidant capacity of the brain.

TL;DR: The results show that chronic exposure to low levels of arsenic causes subtle but region-specific changes in the nervous system, especially in antioxidant systems and dopaminergic elements.

TL;DR: Results indicate that in mice, GSH depletion is associated with p38(MAPK) phosphorylation in the liver and kidney and with ERK2 activation in the brain, in what could be considered part of the brain's protective response to thiol depletion.