J
Joris van der Veeken
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 21
Citations - 4425
Joris van der Veeken is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: FOXP3 & Transcription factor. The author has an hindex of 12, co-authored 18 publications receiving 3292 citations. Previous affiliations of Joris van der Veeken include Cornell University & Research Institute of Molecular Pathology.
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Journal ArticleDOI
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Nicholas Arpaia,Clarissa Campbell,Xiying Fan,Stanislav Dikiy,Joris van der Veeken,Paul deRoos,Hui Liu,Justin R. Cross,Klaus Pfeffer,Paul J. Coffer,Alexander Y. Rudensky +10 more
TL;DR: The results suggest that bacterial metabolites mediate communication between the commensal microbiota and the immune system, affecting the balance between pro- and anti-inflammatory mechanisms.
Journal ArticleDOI
Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus
Yongqiang Feng,Aaron Arvey,Takatoshi Chinen,Joris van der Veeken,Georg Gasteiger,Alexander Y. Rudensky +5 more
TL;DR: CNS2-mediated stable inheritance of Foxp3 expression is critical for adequate suppression of diverse types of chronic inflammation by Treg cells and prevents their differentiation into inflammatory effector cells.
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Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells
Aaron Arvey,Joris van der Veeken,Robert M. Samstein,Yongqiang Feng,John A. Stamatoyannopoulos,Alexander Y. Rudensky +5 more
TL;DR: Foxp3 poises its targets for repression by facilitating the formation of repressive chromatin in Treg cells upon their activation in response to inflammatory cues.
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Downregulation of EGFR by a novel multivalent nanobody-liposome platform
Sabrina Oliveira,Raymond M. Schiffelers,Joris van der Veeken,Roy van der Meel,Ranitha Vongpromek,Paul M.P. van Bergen en Henegouwen,Gert Storm,Rob C. Roovers +7 more
TL;DR: In this study, a multivalent platform is presented, consisting of nanobodies recognizing the ectodomain of EGFR (EGa1) coupled to PEG-liposomes, and the in vitro and in vivo effects of this system on EGFR internalization and downregulation were investigated.
Journal ArticleDOI
Memory of Inflammation in Regulatory T Cells.
Joris van der Veeken,Alvaro J. González,Hyunwoo Cho,Aaron Arvey,Saskia Hemmers,Christina S. Leslie,Alexander Y. Rudensky +6 more
TL;DR: It is found that the inflammation-experienced Treg cell population reversed many activation-induced changes and lost its enhanced suppressive function over time, suggesting the "memory-less" potentiation of Treg suppressor function may help avoid a state of generalized immunosuppression that could otherwise result from repeated activation.