J
Jos A. E. Spaan
Researcher at University of Amsterdam
Publications - 212
Citations - 12020
Jos A. E. Spaan is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Fractional flow reserve & Coronary circulation. The author has an hindex of 55, co-authored 211 publications receiving 11322 citations. Previous affiliations of Jos A. E. Spaan include Utrecht University.
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Journal ArticleDOI
Physiological Assessment of Coronary Artery Disease in the Cardiac Catheterization Laboratory A Scientific Statement From the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology
Morton J. Kern,Amir Lerman,Jan Willen Bech,Bernard De Bruyne,Eric Eeckhout,William F. Fearon,Stuart T. Higano,Michael J. Lim,Martijn Meuwissen,Jan J. Piek,Nico H.J. Pijls,Maria Siebes,Jos A. E. Spaan +12 more
TL;DR: The goal of this statement is to provide a logical approach to the use of coronary physiological measurements in the catheterization lab to assist both clinicians and investigators in improving patient care.
Journal ArticleDOI
The Endothelial Glycocalyx Protects Against Myocardial Edema
TL;DR: This paper showed that the rat myocardial capillary endothelial surface is coated with a 0.2-to 0.5-μm-thick carbohydrate layer and that its degradation instantly results in notable myocardia tissue edema.
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Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes
Max Nieuwdorp,Hans L. Mooij,Jojanneke Kroon,Bektaş Atasever,Jos A. E. Spaan,Can Ince,Frits Holleman,Michaela Diamant,Robert J. Heine,Joost B. L. Hoekstra,John J.P. Kastelein,Erik S.G. Stroes,Hans Vink +12 more
TL;DR: Type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria and plasma hyaluronan, a principal glycocalyX constituent, andhyaluronidase were increased in type 1 diabetes.
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Pressure-flow relations in coronary circulation
TL;DR: In this review, the physics of collapsible tubes is described, the possible occurrences of vascular waterfalls in the body is evaluated, and the evidence that intramural coronary vessels act like vascular water falls is inconclusive.
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Oxidized Lipoproteins Degrade the Endothelial Surface Layer Implications for Platelet-Endothelial Cell Adhesion
TL;DR: In this paper, a hamster cremaster muscle preparation was used for intravital microscopic observation of the distance between erythrocytes and the capillary EC surface, and the authors hypothesized that the disruption of the endothelial surface layer by oxidized low-density lipoproteins contributes to atherogenic increases in vascular wall adhesiveness.