scispace - formally typeset
J

Jos A. E. Spaan

Researcher at University of Amsterdam

Publications -  212
Citations -  12020

Jos A. E. Spaan is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Fractional flow reserve & Coronary circulation. The author has an hindex of 55, co-authored 211 publications receiving 11322 citations. Previous affiliations of Jos A. E. Spaan include Utrecht University.

Papers
More filters
Journal ArticleDOI

The Endothelial Glycocalyx Protects Against Myocardial Edema

TL;DR: This paper showed that the rat myocardial capillary endothelial surface is coated with a 0.2-to 0.5-μm-thick carbohydrate layer and that its degradation instantly results in notable myocardia tissue edema.
Journal ArticleDOI

Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes

TL;DR: Type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria and plasma hyaluronan, a principal glycocalyX constituent, andhyaluronidase were increased in type 1 diabetes.
Journal ArticleDOI

Pressure-flow relations in coronary circulation

TL;DR: In this review, the physics of collapsible tubes is described, the possible occurrences of vascular waterfalls in the body is evaluated, and the evidence that intramural coronary vessels act like vascular water falls is inconclusive.
Journal ArticleDOI

Oxidized Lipoproteins Degrade the Endothelial Surface Layer Implications for Platelet-Endothelial Cell Adhesion

TL;DR: In this paper, a hamster cremaster muscle preparation was used for intravital microscopic observation of the distance between erythrocytes and the capillary EC surface, and the authors hypothesized that the disruption of the endothelial surface layer by oxidized low-density lipoproteins contributes to atherogenic increases in vascular wall adhesiveness.