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Bernard De Bruyne
Researcher at Eindhoven University of Technology
Publications - 465
Citations - 43780
Bernard De Bruyne is an academic researcher from Eindhoven University of Technology. The author has contributed to research in topics: Fractional flow reserve & Coronary artery disease. The author has an hindex of 88, co-authored 399 publications receiving 38144 citations.
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Journal ArticleDOI
Fractional flow reserve versus angiography for guiding percutaneous coronary intervention
Bernard De Bruyne,Uwe Siebert,Fumiaki Ikeno,Volker Klauss,Ganesh Manoharan,Thomas Engstrøm,Keith G. Oldroyd,Peter N. Ver Lee,Philip MacCarthy,William F. Fearon +9 more
TL;DR: Routine measurement of FFR in patients with multivessel coronary artery disease who are undergoing PCI with drug-eluting stents significantly reduces the rate of the composite end point of death, nonfatal myocardial infarction, and repeat revascularization at 1 year.
Journal ArticleDOI
A Prospective Natural-History Study of Coronary Atherosclerosis
Gregg W. Stone,Akiko Maehara,Alexandra J. Lansky,Bernard De Bruyne,Ecaterina Cristea,Gary S. Mintz,Roxana Mehran,John A. McPherson,Naim Farhat,Steven P. Marso,Helen Parise,Barry Templin,Roseann White,Zhen Zhang,Patrick W. Serruys +14 more
TL;DR: In patients who presented with an acute coronary syndrome and underwent percutaneous coronary intervention, major adverse cardiovascular events occurring during follow-up were equally attributable to recurrence at the site of culprit lesions and to nonculprit lesions.
Journal ArticleDOI
Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
Bernard De Bruyne,Bindu Kalesan,Emanuele Barbato,Zsolt Piroth,Nikola Jagic,Sven Mobius-Winckler,Gilles Rioufol,Nils Witt,Petr Kala,Philip MacCarthy,Thomas Engstrøm,Keith G. Oldroyd,Kreton Mavromatis,Ganesh Manoharan,Peter Verlee,Ole Fröbert,Nick Curzen,Jane B. Johnson,Peter Jüni,William F. Fearon,Trial Investigators +20 more
TL;DR: In patients with stable coronary artery disease and functionally significant stenoses, FFR-guided PCI plus the best available medical therapy, as compared with the best Available medical therapy alone, decreased the need for urgent revascularization.
Journal ArticleDOI
Measurement of Fractional Flow Reserve to Assess the Functional Severity of Coronary-Artery Stenoses
Nico H.J. Pijls,Bernard De Bruyne,Kathinka H. Peels,Pepijn H. van der Voort,Hans Bonnier,Jozef Bartunek,Jacques J. Koolen +6 more
TL;DR: In patients with coronary stenosis of moderate severity, FFR appears to be a useful index of the functional severity of the stenoses and the need for coronary revascularization.
Journal ArticleDOI
Percutaneous Coronary Intervention of Functionally Nonsignificant Stenosis: 5-Year Follow-Up of the DEFER Study
Nico H.J. Pijls,Pepijn van Schaardenburgh,Ganesh Manoharan,Eric Boersma,Jan-Willem Bech,Marcel van 't Veer,Frits W. Bär,Jan C.A. Hoorntje,Jacques J. Koolen,William Wijns,Bernard De Bruyne +10 more
TL;DR: Five-year outcome after deferral of PCI of an intermediate coronary stenosis based on FFR >/=0.75 is excellent and the risk of cardiac death or myocardial infarction related to this stenosis is <1% per year and not decreased by stenting.