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Josbert M. Metselaar

Researcher at RWTH Aachen University

Publications -  115
Citations -  5358

Josbert M. Metselaar is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Liposome & Drug delivery. The author has an hindex of 37, co-authored 107 publications receiving 4224 citations. Previous affiliations of Josbert M. Metselaar include University of Innsbruck & Utrecht University.

Papers
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Journal ArticleDOI

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

Susan Hua, +6 more
- 17 Jul 2018 - 
TL;DR: Key issues related to the clinical development of NNMs will be covered, including biological challenges, large-scale manufacturing, biocompatibility and safety, intellectual property (IP), government regulations, and overall cost-effectiveness in comparison to current therapies.
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Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes

Josbert M. Metselaar, +4 more
- 01 Jul 2003 - 
TL;DR: Evidence was found that preferential glucocorticoid delivery to the inflamed joint was the key factor explaining the observed strong therapeutic benefit obtained with the liposomal preparation, while other possible mechanisms, such as splenic accumulation or prolonged release of prednisolone in the circulation, were excluded.
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Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes.

Maria Coimbra, +11 more
- 20 Sep 2011 - 
TL;DR: Despite the instability of liposome-association of 3-oxo-C(12)-homoserine lactone and resveratrol, intravenous administration of these compounds inhibited tumor growth for approximately 70% in a murine tumor model, showing that simple solubilization can have important therapeutic benefits.
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Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis.

Jens Schmidt, +5 more
- 01 Aug 2003 - 
TL;DR: PL is a highly effective drug in treatment of EAE, and is superior to a 5-fold higher dose of free MP, possibly by means of drug targeting, and may have implications for future therapy of autoimmune disorders such as multiple sclerosis.
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Role of complement activation in hypersensitivity reactions to doxil and hynic PEG liposomes: experimental and clinical studies.

Janos Szebeni, +13 more
- 15 Jul 2002 - 
TL;DR: The data suggest that liposome-induced HSRs in susceptible individuals may be due to C activation, which, in turn, is due to the presence of negatively charged PEG-PE in these vesicles.