L
Louis van Bloois
Researcher at Utrecht University
Publications - 42
Citations - 2938
Louis van Bloois is an academic researcher from Utrecht University. The author has contributed to research in topics: Antigen & Liposome. The author has an hindex of 25, co-authored 39 publications receiving 2586 citations. Previous affiliations of Louis van Bloois include Icahn School of Medicine at Mount Sinai & Eindhoven University of Technology.
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Journal ArticleDOI
Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes.
Maria Coimbra,Benedetta Isacchi,Louis van Bloois,Javier Sastre Toraño,Aldo Ket,Xiaojie Wu,Femke Broere,Josbert M. Metselaar,Cristianne J.F. Rijcken,Gert Storm,Rita Bilia,Raymond M. Schiffelers +11 more
TL;DR: Despite the instability of liposome-association of 3-oxo-C(12)-homoserine lactone and resveratrol, intravenous administration of these compounds inhibited tumor growth for approximately 70% in a murine tumor model, showing that simple solubilization can have important therapeutic benefits.
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A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets.
Willem J. M. Mulder,Gustav J. Strijkers,Arjan W. Griffioen,Louis van Bloois,Grietje Molema,Gert Storm,Gerben A. Koning,Klaas Nicolay +7 more
TL;DR: This study suggests that this newly developed pegylated paramagnetic fluorescently labeled liposomes may serve as a useful diagnostic tool to investigate pathological processes in vivo with MRI.
Journal ArticleDOI
Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics.
Sybren L. N. Maas,Jeroen de Vrij,Els J. van der Vlist,Biaina Geragousian,Louis van Bloois,Enrico Mastrobattista,Raymond M. Schiffelers,Marca H. M. Wauben,Marike L. D. Broekman,Esther N. M. Nolte-‘t Hoen +9 more
TL;DR: This study investigated the possibilities, limitations and comparability of NTA, tRPS and hFC for analysis of tumor cell-derived EVs and synthetic mimics and detailed the differences in absolute quantification of EVs and liposomes using the three technologies.
Journal ArticleDOI
Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis
Pilar Barrera,Arjen B. Blom,Peter L E M van Lent,Louis van Bloois,Jos H. Beijnen,Nico van Rooijen,Maarten C. De Waal Malefijt,Leo B. A. Van De Putte,Gert Storm,Wim B. van den Berg +9 more
TL;DR: A single IA administration of clodronate liposomes leads to macrophage depletion and decreased expression of adhesion molecules in the synovial lining in patients with longstanding RA, and its therapeutic potential is currently under investigation.
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A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice.
Rozemarijn S. van Rijn,Elles R. Simonetti,Anton Hagenbeek,Marieke C. H. Hogenes,Roel A. de Weger,Marijke R. Canninga-van Dijk,Kees Weijer,Hergen Spits,Gert Storm,Louis van Bloois,Ger T. Rijkers,Anton C.M. Martens,Saskia B. Ebeling +12 more
TL;DR: A new model for xenogeneic GVHD (X-GVHD) by intravenous transfer of huPBMCs into RAG2-/- gammac-/- mice is developed, with a high human T-cell chimerism associated with a consistent development of XGVHD within 14 to 28 days and a total mortality rate of 85% shorter than 2 months.