José A. Botella

TL;DR: It is proposed that in FA, the oxidative mediated inactivation of aconitase, which occurs normally during the aging process, is enhanced due to the lack of frataxin, and an important role of oxidative stress in the progression of FA is supported.

TL;DR: Results clearly support a strong involvement of glial cells and lipid peroxidation in the generation of FRDA-like symptoms and co-expression of a Drosophila apolipoprotein D ortholog has a strong protective effect in frataxin models, mainly by controlling the level of lipidperoxidation.

TL;DR: It is shown that dopaminergic neurons are specifically sensitive to hyperoxia induced oxidative stress and that mutant forms of alpha-synuclein show an enhanced toxicity under these conditions suggesting synergic interactions, identifying oxidative stress as an important causative factor in the pathology of autosomal-dominant Parkinsonism.

TL;DR: This review analyzes how the use of fruit flies has revealed to be an excellent tool providing valuable insights into the current understanding of the molecular mechanisms involved in the progression of PD.

TL;DR: It is demonstrated that oxidative stress is a direct cause of neurodegeneration in the Drosophila central nervous system and that reduction of sniffer activity leads to neuronal cell death.