J
José A Fernández
Researcher at Queen's University Belfast
Publications - 16
Citations - 4593
José A Fernández is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Retinal & Transient receptor potential channel. The author has an hindex of 10, co-authored 16 publications receiving 1621 citations.
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Journal ArticleDOI
QuPath: Open source software for digital pathology image analysis
Peter Bankhead,Maurice B Loughrey,Maurice B Loughrey,José A Fernández,Yvonne Dombrowski,Darragh G. McArt,Philip D Dunne,Stephen McQuaid,Stephen McQuaid,Ronan T. Gray,Liam J. Murray,Helen G. Coleman,Jacqueline A James,Jacqueline A James,Manuel Salto-Tellez,Manuel Salto-Tellez,Peter W. Hamilton +16 more
TL;DR: QuPath provides researchers with powerful batch-processing and scripting functionality, and an extensible platform with which to develop and share new algorithms to analyze complex tissue images, making it suitable for a wide range of additional image analysis applications across biomedical research.
Posted ContentDOI
QuPath: Open source software for digital pathology image analysis
Peter Bankhead,Maurice B Loughrey,José A Fernández,Yvonne Dombrowski,Darragh G. McArt,Philip D Dunne,Stephen McQuaid,Ronan T. Gray,Liam J. Murray,Helen G. Coleman,Jacqueline A James,Manuel Salto-Tellez,Peter W. Hamilton +12 more
TL;DR: QuPath provides researchers with powerful batch-processing and scripting functionality, and an extensible platform with which to develop and share new algorithms to analyze complex tissue images, making it suitable for a wide range of additional image analysis applications across biomedical research.
Journal ArticleDOI
Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer.
Peter Bankhead,José A Fernández,Darragh G. McArt,David P Boyle,Gerald Li,Maurice B Loughrey,Maurice B Loughrey,Gareth Irwin,D. Paul Harkin,Jacqueline James,Jacqueline James,Stephen McQuaid,Stephen McQuaid,Manuel Salto-Tellez,Manuel Salto-Tellez,Peter W. Hamilton +15 more
TL;DR: Automated DIA using a new purpose-built software platform (QuPath) is applied to a cohort of 293 breast cancer patients to score five biomarkers in tissue microarrays, demonstrating QuPath’s suitability for fast, reproducible, high-throughput TMA analysis across a range of important biomarkers.
Journal ArticleDOI
Voltage- and cold-dependent gating of single TRPM8 ion channels
José A Fernández,Roman Skryma,Gabriel Bidaux,Karl L. Magleby,C. Norman Scholfield,J. Graham McGeown,Natalia Prevarskaya,Alexander Zholos +7 more
TL;DR: A seven-state model provides a general mechanism to account for TRPM8 activation by membrane depolarization at two temperatures and can serve as a starting point for further investigations of multimodal TRP activation.
Journal ArticleDOI
Regulation of Activity of Transient Receptor Potential Melastatin 8 (TRPM8) Channel by Its Short Isoforms
Gabriel Bidaux,Benjamin Beck,Alexander Zholos,Dmitri V. Gordienko,Loic Lemonnier,Matthieu Flourakis,Morad Roudbaraki,Anne-Sophie Borowiec,José A Fernández,Philippe Delcourt,Gilbert Lepage,Yaroslav M. Shuba,Roman Skryma,Natalia Prevarskaya +13 more
TL;DR: A new mode of regulation of the TRPM8 channel by its splice variants is uncovered, resulting in stabilization of its closed state and thus reducing both its cold sensitivity and activity.