J
Jose A. Gavira
Researcher at Spanish National Research Council
Publications - 129
Citations - 3421
Jose A. Gavira is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Crystallization & Protein crystallization. The author has an hindex of 28, co-authored 112 publications receiving 2841 citations. Previous affiliations of Jose A. Gavira include Tohoku University & University of Alabama in Huntsville.
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N-succinylamino acid racemases: Enzymatic properties and biotechnological applications.
TL;DR: This review aims to gather the dispersed information on NSAR/OSBS members showing NxAR activity over recent decades, focusing on their biotechnological applications and providing practical advice to identify new enzymes.
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In situ X‐ray data collection from highly sensitive crystals of Pseudomonas putida PtxS in complex with DNA
Estela Pineda-Molina,Abdelali Daddaoua,Tino Krell,Juan L. Ramos,Juan Manuel García-Ruiz,Jose A. Gavira +5 more
TL;DR: Crystallization of native P TXS failed, and PtxS-DNA crystals were finally produced by the counter-diffusion technique, using a portion of the capillary used for crystal growth and directly flash-cooled in liquid nitrogen for diffraction tests.
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Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation
Albert Castellví,Isidro Crespo,Eva Crosas,Ana Cámara-Artigas,Jose A. Gavira,Miguel A. G. Aranda,Xavier Parés,Jaume Farrés,Judith Juanhuix +8 more
TL;DR: It is proposed that hAR inhibitors should not be designed against the native protein but against the activated form as obtained from X-ray irradiation, since the reactive species produced under irradiation conditions are the same as those produced under oxidative stress, and the described irradiation method can be applied to other relevant proteins under oxidative Stress environments.
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Understanding the polymorphic behaviour of a mutant of the α‐spectrin SH3 domain by means of two 1.1 Å resolution structures
Ana Cámara-Artigas,Jose A. Gavira,Salvador Casares,Juan Manuel García-Ruiz,Francisco Conejero-Lara,James P. Allen,Jose C. Martinez +6 more
TL;DR: When both polymorphs of the R21D mutant of Spc-SH3 are simultaneously present into the same solution, it has been observed that the hexagonal crystals grow at the expense of the orthorhombic crystals.
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In-situ measurement of rocking curves during lysozyme crystal growth.
TL;DR: The rocking curves recorded in situ from growing crystals are easier to understand than those from crystals that have suffered even minor handling, and are used to assess the mosaicity of tetragonal lysozyme crystals during crystal growth.