J
José Escolano
Researcher at Spanish National Research Council
Publications - 11
Citations - 1207
José Escolano is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Venom & Antivenom. The author has an hindex of 10, co-authored 11 publications receiving 1131 citations.
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Journal ArticleDOI
Snake Venomics of the Lancehead Pitviper Bothrops asper: Geographic, Individual, and Ontogenetic Variations
Alberto Alape-Girón,Libia Sanz,José Escolano,Marietta Flores-Díaz,Marvin Madrigal,Mahmood Sasa,Juan J. Calvete +6 more
TL;DR: This study represents the first detailed characterization of individual and ontogenetic venom protein profile variations in two geographical isolated B. asper populations, and highlights the necessity of using pooled venoms as a statistically representative venom for antivenom production.
Journal ArticleDOI
Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii
Bruno Lomonte,José Escolano,Julián Fernández,Libia Sanz,Yamileth Angulo,José María Gutiérrez,Juan J. Calvete +6 more
TL;DR: The results provide a ground for rationalizing the reported protection of the ICP polyvalent antivenom against the hemorrhagic, coagulant, defibrinating, caseinolytic and fibrin(ogen)olytic activities of Bothriechis ( schlegelii, lateralis) venoms.
Journal ArticleDOI
Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom.
José María Gutiérrez,Libia Sanz,José Escolano,Julián Fernández,Bruno Lomonte,Yamileth Angulo,Alexandra Rucavado,David A. Warrell,Juan J. Calvete +8 more
TL;DR: The venoms of these two species differed in the composition and the relative abundance of their component toxins, but they exhibited similar toxicological and enzymatic profiles in mice, characterized by lethal, hemorrhagic, edema-forming, phospholipase A 2 and proteolytic activities.
Journal ArticleDOI
Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis.
Libia Sanz,José Escolano,Massimo Ferretti,Mirtha J. Biscoglio,Elena Rivera,Ernesto Crescenti,Yamileth Angulo,Bruno Lomonte,José María Gutiérrez,Juan J. Calvete +9 more
TL;DR: In this article, the authors report the proteomic characterization of the venoms of two closely related pit vipers of the genus Lachesis, L. muta and L. stenophrys, and compare the toxin repertoire of the former revealed through a proteomic versus a transcriptomic approach.
Snake venomics of the South and Central American bushmasters. Comparisonof the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis
Libia Sanz,José Escolano,Massimo Ferretti,Mirtha J. Biscoglio,Yamileth Angulo,B. Lomonte,José María Gutiérrez,Juan J. Calvete +7 more
TL;DR: Observations indicate that these class of toxins represents a rapidly-evolving gene family, and suggests that functional differences due to structural changes in PLA(2)s molecules among these snakes may have been a hallmark during speciation and adaptation of diverging snake populations to new ecological niches, or competition for resources in existing ones.