J
José Leiva
Researcher at University of Navarra
Publications - 55
Citations - 1994
José Leiva is an academic researcher from University of Navarra. The author has contributed to research in topics: Antibiotics & Respiratory infection. The author has an hindex of 17, co-authored 51 publications receiving 1780 citations. Previous affiliations of José Leiva include Hospital General Universitario Gregorio Marañón.
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Journal ArticleDOI
The Enterococcal Surface Protein, Esp, Is Involved in Enterococcus faecalis Biofilm Formation
Alejandro Toledo-Arana,Jaione Valle,Cristina Solano,Marı́a Jesús Arrizubieta,Carme Cucarella,Marta Lamata,Beatriz Amorena,José Leiva,José R. Penadés,Iñigo Lasa +9 more
TL;DR: It is demonstrated that biofilm formation capacity is widespread among clinical E. faecalis isolates, the biofilmformation capacity is restricted to the E.Faecalis strains harboringesp, and Esp promotes primary attachment and biofilm Formation of E. Faecalis on abiotic surfaces.
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Antibiotic susceptibility assay for Staphylococcus aureus in biofilms developed in vitro
Beatriz Amorena,Elena Gracia,Marta Monzón,José Leiva,Concepción Oteiza,Marta M. Pérez,José-Luis Alabart,José Hernández-Yago +7 more
TL;DR: Transmission electron microscopy revealed that cells at the inner biofilm layers tend to remain intact after antibiotic treatment and that TSB-grown biofilms favoured a uniformity of cell distribution and increased cell density in comparison with milk-grownBiofilm aged revealed a reduced matrix distribution and enhanced cell density were observed as the biofilm aged.
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Evaluation of the relatedness of Brucella spp. and Ochrobactrum anthropi and description of Ochrobactrum intermedium sp. nov., a new species with a closer relationship to Brucella spp.
TL;DR: Results show that the LMG 3301 cluster and related clinical isolates should be given a new species status for which the name Ochrobactrum intermedium sp.
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Synergy of different antibiotic combinations in biofilms of Staphylococcus epidermidis
TL;DR: Results indicate that the biofilm test applied allows the detection of synergy between antibiotics and suggests that this assay could be useful in clinical and extensive synergy studies on S. epidermidis biofilms.
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Biofilm testing of Staphylococcus epidermidis clinical isolates: low performance of vancomycin in relation to other antibiotics.
TL;DR: The in vitro killing effect of widely used antibiotics was comparatively analyzed on 24-h biofilms of 64 Staphylococcus epidermidis clinical isolates to underline the relevance of biofilm susceptibility testing and the potential danger of the indiscriminate use of vancomycin monotherapy as the ultimate resource against infections involving aged bioFilms.