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Alejandro Toledo-Arana
Researcher at Spanish National Research Council
Publications - 60
Citations - 5696
Alejandro Toledo-Arana is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Gene & Biofilm matrix. The author has an hindex of 30, co-authored 55 publications receiving 5153 citations. Previous affiliations of Alejandro Toledo-Arana include French Institute of Health and Medical Research & Universidad Pública de Navarra.
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Journal ArticleDOI
The Listeria transcriptional landscape from saprophytism to virulence
Alejandro Toledo-Arana,Olivier Dussurget,Olivier Dussurget,Olivier Dussurget,Georgios Nikitas,Georgios Nikitas,Nina Sesto,Nina Sesto,Nina Sesto,Hélène Guet-Revillet,Hélène Guet-Revillet,Hélène Guet-Revillet,Damien Balestrino,Damien Balestrino,Damien Balestrino,Edmund Loh,Jonas Gripenland,Teresa Tiensuu,Karolis Vaitkevicius,Mathieu Barthelemy,Massimo Vergassola,Massimo Vergassola,Marie-Anne Nahori,Marie-Anne Nahori,Marie-Anne Nahori,Guillaume Soubigou,Béatrice Regnault,Jean-Yves Coppée,Marc Lecuit,Jörgen Johansson,Pascale Cossart,Pascale Cossart,Pascale Cossart +32 more
TL;DR: Using tiling arrays and RNAs from wild-type and mutant bacteria grown in vitro, ex vivo and in vivo, the transcription of its entire genome is analysed and it is discovered that riboswitches can act as terminators for upstream genes.
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The Enterococcal Surface Protein, Esp, Is Involved in Enterococcus faecalis Biofilm Formation
Alejandro Toledo-Arana,Jaione Valle,Cristina Solano,Marı́a Jesús Arrizubieta,Carme Cucarella,Marta Lamata,Beatriz Amorena,José Leiva,José R. Penadés,Iñigo Lasa +9 more
TL;DR: It is demonstrated that biofilm formation capacity is widespread among clinical E. faecalis isolates, the biofilmformation capacity is restricted to the E.Faecalis strains harboringesp, and Esp promotes primary attachment and biofilm Formation of E. Faecalis on abiotic surfaces.
Journal ArticleDOI
SarA and not σB is essential for biofilm development by Staphylococcus aureus
Jaione Valle,Alejandro Toledo-Arana,Carmen Berasain,Jean-Marc Ghigo,Beatriz Amorena,José R. Penadés,Iñigo Lasa +6 more
TL;DR: It is proposed that SarA activates S. aureus development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be σB‐dependent.
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BapA, a large secreted protein required for biofilm formation and host colonization of Salmonella enterica serovar Enteritidis
Cristina Latasa,Agnès Roux,Alejandro Toledo-Arana,Jean-Marc Ghigo,Carlos Gamazo,José R. Penadés,Iñigo Lasa +6 more
TL;DR: Evidence that overproduction of curli fimbriae and not cellulose can compensate for the biofilm deficiency of a bapA mutant strain is provided, demonstrating that BapA contributes both to biofilm formation and invasion through the regular Salmonella infection route.
Journal ArticleDOI
Protein A-mediated multicellular behavior in Staphylococcus aureus.
Nekane Merino,Alejandro Toledo-Arana,Marta Vergara-Irigaray,Jaione Valle,Cristina Solano,Enrique Calvo,Juan Antonio López,Timothy J. Foster,José R. Penadés,Iñigo Lasa +9 more
TL;DR: A murine model of subcutaneous catheter infection unveiled a significant role for protein A in the development of biofilm-associated infections, as the amount of protein A-deficient bacteria recovered from the catheter was significantly lower than that of wild-type bacteria when both strains were used to coinfect the implanted medical device.