J
José R. Penadés
Researcher at Imperial College London
Publications - 129
Citations - 11006
José R. Penadés is an academic researcher from Imperial College London. The author has contributed to research in topics: Pathogenicity island & Bacteriophage. The author has an hindex of 49, co-authored 119 publications receiving 9303 citations. Previous affiliations of José R. Penadés include CEU Cardinal Herrera University & University of Glasgow.
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Journal ArticleDOI
Bap, a Staphylococcus aureus surface protein involved in biofilm formation.
TL;DR: In a mouse infection model bap was involved in pathogenesis, causing a persistent infection, and all staphylococcal isolates harboring bap were highly adherent and strong biofilm producers.
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The Enterococcal Surface Protein, Esp, Is Involved in Enterococcus faecalis Biofilm Formation
Alejandro Toledo-Arana,Jaione Valle,Cristina Solano,Marı́a Jesús Arrizubieta,Carme Cucarella,Marta Lamata,Beatriz Amorena,José Leiva,José R. Penadés,Iñigo Lasa +9 more
TL;DR: It is demonstrated that biofilm formation capacity is widespread among clinical E. faecalis isolates, the biofilmformation capacity is restricted to the E.Faecalis strains harboringesp, and Esp promotes primary attachment and biofilm Formation of E. Faecalis on abiotic surfaces.
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SarA and not σB is essential for biofilm development by Staphylococcus aureus
Jaione Valle,Alejandro Toledo-Arana,Carmen Berasain,Jean-Marc Ghigo,Beatriz Amorena,José R. Penadés,Iñigo Lasa +6 more
TL;DR: It is proposed that SarA activates S. aureus development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be σB‐dependent.
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Role of Biofilm-Associated Protein Bap in the Pathogenesis of Bovine Staphylococcus aureus
Carme Cucarella,M. Ángeles Tormo,Carles Ubeda,M. Pilar Trotonda,Marta Monzón,Critòfol Peris,Beatriz Amorena,Iñigo Lasa,José R. Penadés +8 more
TL;DR: It is demonstrated that, in the bovine intramammary gland, the presence of Bap may facilitate a biofilm formation connected with the persistence of S. aureus.
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The phage-related chromosomal islands of Gram-positive bacteria.
TL;DR: The shared genetic content of phage-related chromosomal islands is discussed, their life cycle and their ability to be transferred across large phylogenetic distances are discussed.