J
José M. Cuevas
Researcher at University of Valencia
Publications - 64
Citations - 2495
José M. Cuevas is an academic researcher from University of Valencia. The author has contributed to research in topics: Viral evolution & Virus. The author has an hindex of 24, co-authored 63 publications receiving 2189 citations. Previous affiliations of José M. Cuevas include University of Oxford & Polytechnic University of Valencia.
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Journal ArticleDOI
Extremely High Mutation Rate of HIV-1 In Vivo.
TL;DR: The intrapatient frequency of premature stop codons is used to quantify the HIV-1 genome-wide rate of spontaneous mutation in DNA sequences from peripheral blood mononuclear cells, revealing an extremely high mutation rate, the highest reported for any biological entity.
Journal ArticleDOI
Selection for robustness in mutagenized RNA viruses.
Rafael Sanjuán,Rafael Sanjuán,José M. Cuevas,Victoria Furió,Edward C. Holmes,Edward C. Holmes,Andrés Moya +6 more
TL;DR: Results show that selection can directly favor mutational robustness and reveal a novel viral resistance mechanism against treatment by lethal mutagenesis.
Journal ArticleDOI
Effect of Ribavirin on the Mutation Rate and Spectrum of Hepatitis C Virus In Vivo
TL;DR: A roughly threefold increase in mutation rate and a significant shift in mutation spectrum were observed in samples from patients undergoing 6 months of interferon plus ribavirin treatment, suggesting that the antiviral effect of Ribavirin plus interferons treatment is at least partly exerted through lethal mutagenesis.
Journal ArticleDOI
The evolutionary genetics of emerging plant RNA viruses.
Santiago F. Elena,Stéphanie Bedhomme,Purificación Carrasco,José M. Cuevas,Francisca de la Iglesia,Guillaume Lafforgue,Jasna Lalić,Àngels Pròsper,Nicolas Tromas,Mark P. Zwart +9 more
TL;DR: The present review puts emergence of plant RNA viruses into the framework of evolutionary genetics, stressing that viral emergence begins with a stochastic process that involves the transmission of a preexisting viral strain into a new host species, followed by adaptation to the new host.
Journal ArticleDOI
The fitness effects of random mutations in single-stranded DNA and RNA bacteriophages.
TL;DR: High mutational sensitivity is a general property of viruses with small genomes, including those infecting animals, plants, and bacteria, which can contribute to explain the evolution of ssDNA and ssRNA viruses.