Raquel Garijo

TL;DR: The intrapatient frequency of premature stop codons is used to quantify the HIV-1 genome-wide rate of spontaneous mutation in DNA sequences from peripheral blood mononuclear cells, revealing an extremely high mutation rate, the highest reported for any biological entity.

TL;DR: This work characterized the genetic structure and diversity of a RNA virus shortly after single-cell bottlenecks and revealed that sequence variants pre-existing in different viral genomes can be co-transmitted within the same infectious unit to individual cells.

TL;DR: It is found that mutability correlates with the ability of HCV to diversify in patients, and base composition, the presence of high- and low-mutation clusters and transition/transversion biases are the main factors driving this heterogeneity.

TL;DR: The results show that RNA viruses can be specifically adapted typical cancer features such as p53 inactivation, and illustrate the usefulness of experimental evolution for oncolytic virotherapy.

TL;DR: The intra-patient diversity of the NoV capsid is analyzed by carrying out RT-PCR and ultra-deep sequencing with 100,000-fold coverage of 16 stool samples from symptomatic patients to suggest a role for hyper-mutation in NoV diversity and the type of changes produced are compatible with ADAR-mediated editing of the viral RNA.