J
José Méndez-Andino
Researcher at Procter & Gamble
Publications - 28
Citations - 461
José Méndez-Andino is an academic researcher from Procter & Gamble. The author has contributed to research in topics: Metathesis & Ring (chemistry). The author has an hindex of 12, co-authored 28 publications receiving 455 citations. Previous affiliations of José Méndez-Andino include Ohio State University.
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Journal ArticleDOI
Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents.
Namal Chithranga Warshakoon,Justin Sheville,Ritu Tiku Bhatt,Wei Ji,José Méndez-Andino,Kenneth M. Meyers,Nick K. Kim,John August Wos,Chrissy Mitchell,Jennifer L. Paris,Beth B. Pinney,Ofer Reizes,X. Eric Hu +12 more
TL;DR: A novel series of substituted quinoline analogs were designed and synthesized as potent and selective melanin concentrating hormone (MCH) antagonists and showed improved activity in MCH-1R and selectivity over 5HT2C.
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MCH-R1 antagonists: what is keeping most research programs away from the clinic?
TL;DR: Drug-design strategies, in vivo efficacy, ADME, and cardiovascular safety profiles for a selection of MCH-R1 antagonist research programs are discussed ahead.
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A direct, highly convergent route to α-methylene-γ-lactones fused to medium and large rings
TL;DR: In this article, a general procedure for the synthesis of α-methylene lactones cis- or trans-fused to larger rings is described, which originates with two ω-unsaturated aldehydes of the same or different chain length.
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Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity
Nick K. Kim,Kenneth M. Meyers,José Méndez-Andino,Namal Chithranga Warshakoon,Wei Ji,John August Wos,Anny-Odile Colson,M. Chrissy Mitchell,Jan Richard Davis,Beth B. Pinney,Ofer Reizes,X. Eric Hu +11 more
TL;DR: A substituted 4-aminopiperidine was identified as showing activity in an MCH assay from an HTS effort, and subsequent structural modification of the scaffold led to the identification of a number of active MCH antagonists as discussed by the authors.
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Convergent regiodirected assembly of 2,3-disubstituted furans
TL;DR: The conjugate addition of organocopper reagents to alpha, beta-unsaturated enones results in the regiospecific generation of enolate anions, which can be made to undergo the aldol reaction with (tetrahydropyranyloxy)acetaldehyde under zinc chloride catalysis.