J
Josée Mailhot
Researcher at Laval University
Publications - 9
Citations - 273
Josée Mailhot is an academic researcher from Laval University. The author has contributed to research in topics: McMurry reaction & Benzophenone. The author has an hindex of 5, co-authored 9 publications receiving 265 citations.
Papers
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Journal ArticleDOI
(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen
Sylvain Gauthier,Brigitte Caron,Julie Cloutier,Yves L. Dory,Alexandre Favre,Denis Larouche,Josée Mailhot,Carl Ouellet,Annette Schwerdtfeger,Gilles Leblanc,Céline Martel,Jacques Simard,Yves Merand,Alain Bélanger,Claude Labrie,Fernand Labrie +15 more
Journal ArticleDOI
New Highly Stereoselective Synthesis of (Z)-4-Hydroxytamoxifen and (Z)-4-Hydroxytoremifene via McMurry Reaction.
Journal ArticleDOI
Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution.
Sylvain Gauthier,Julie Cloutier,Yves L. Dory,Alexandre Favre,Josée Mailhot,Carl Ouellet,Annette Schwerdtfeger,Yves Merand,Céline Martel,Jacques Simard,Fernand Labrie +10 more
TL;DR: EM-652 (acolbifene) analogs have been synthesized as selective estrogen receptor modulators and 2H-1-Benzopyran 1b (EM-343, racemic form of EM-652), which contains a piperidine ring, shows the best pharmacological profile.
Patent
17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
Fernand Labrie,Gauthier Sylvain,Julie Cloutier,Josée Mailhot,Potvin Steeves,Dion Sylvain,Jean-Yves Sancéau +6 more
TL;DR: In this paper, the structure, their salts or Noxide derivatives are used to treat or reduce le likelihood of acquiring androgendependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness.
Journal ArticleDOI
New Highly Stereoselective Synthesis of (E)-Droloxifene via Selective Protection of 3,4′-Dihydroxybenzophenone and McMurry Reaction
TL;DR: In this paper, a new highly stereoselective synthesis of (E )-droloxifene was reported, based on deprotection of 3,4′-dimethoxybenzophenone and selective pivaloylation of the 3′-phenolic position.