J
Joseph A. Kovacs
Researcher at National Institutes of Health
Publications - 263
Citations - 19363
Joseph A. Kovacs is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Pneumocystis carinii & Pneumocystis pneumonia. The author has an hindex of 69, co-authored 255 publications receiving 18627 citations. Previous affiliations of Joseph A. Kovacs include Science Applications International Corporation & University at Buffalo.
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Journal ArticleDOI
The cardiovascular response of normal humans to the administration of endotoxin
Anthony F. Suffredini,Robert E. Fromm,Margaret M. Parker,Matthew Brenner,Joseph A. Kovacs,Robert Wesley,Joseph E. Parrillo +6 more
TL;DR: It is concluded that the administration of endotoxin to normal subjects causes a depression ofleft ventricular function that is independent of changes in left ventricular volume or vascular resistance, and suggests that endotoxin is a major mediator of the cardiovascular dysfunction in this condition.
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HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
Richard T. Davey,Niranjan Bhat,Christian Yoder,Tae Wook Chun,Julia A. Metcalf,Robin Dewar,Ven Natarajan,Richard A. Lempicki,Joseph W. Adelsberger,Kirk D. Miller,Joseph A. Kovacs,Michael A. Polis,Robert E. Walker,Judith Falloon,Henry Masur,Dennis Gee,Michael Baseler,Dimiter S. Dimitrov,Anthony S. Fauci,H. Clifford Lane +19 more
TL;DR: Ex vivo labeling with BrdUrd showed that CD4 and CD8 cell turnover increased after withdrawal of HAART and correlated with viral load whereas lymphocyte turnover decreased after reinitiation of drug treatment, and Virologic relapse occurs rapidly in patients who discontinue suppressive drug therapy.
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Pneumocystis carinii Pneumonia: A Comparison Between Patients with the Acquired Immunodeficiency Syndrome and Patients with Other Immunodeficiencies
Joseph A. Kovacs,John W. Hiemenz,Abe M. Macher,Diane Stover,Henry W. Murray,James H. Shelhamer,H. Clifford Lane,Carlos Urmacher,Christine L. Honig,Dan L. Longo,Margaret M. Parker,Charles Natanson,Joseph E. Parrillo,Anthony S. Fauci,Philip A. Pizzo,Henry Masur +15 more
TL;DR: Survivors with the acquired immunodeficiency syndrome at initial presentation had a significantly lower respiratory rate, and higher room air arterial oxygen tension, lymphocyte count, and serum albumin level compared to nonsurvivors.
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Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the Fungi
Jeffrey C. Edman,Joseph A. Kovacs,Henry Masur,Daniel V. Santi,Hille J. Elwood,Mitchell L. Sogin +5 more
TL;DR: Phylogenetic analysis of Pneumocystis 16S-like rRNA demonstrates it to be a member of the Fungi, revealing that the plant, animal and fungal lineages are distinct from the diverse spectrum of protozoan lineages.
Journal ArticleDOI
Cryptococcosis in the acquired immunodeficiency syndrome.
Joseph A. Kovacs,Andrea Kovacs,Michael A. Polis,W. Craig Wright,Vee J. Gill,Carmelita U. Tuazon,Edward P. Gelmann,H. Clifford Lane,Robert Longfield,Gary Overturf,Abe M. Macher,Anthony S. Fauci,Joseph E. Parrillo,John E. Bennett,Henry Masur +14 more
TL;DR: Cryptococcosis in patients with the acquired immunodeficiency syndrome is a debilitating disease that does not respond to conventional therapy; earlier diagnosis or long-term suppressive therapy may improve the prognosis.