J
Joseph A. Kuhn
Researcher at Baylor University Medical Center
Publications - 86
Citations - 6447
Joseph A. Kuhn is an academic researcher from Baylor University Medical Center. The author has contributed to research in topics: Sentinel lymph node & Cancer. The author has an hindex of 34, co-authored 86 publications receiving 6184 citations.
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Journal ArticleDOI
The sentinel node in breast cancer--a multicenter validation study.
David N. Krag,Donald L. Weaver,Takamaru Ashikaga,Frederick L. Moffat,V. Suzanne Klimberg,Craig D. Shriver,Sheldon Feldman,Roberto Kusminsky,Michele A. Gadd,Joseph A. Kuhn,Seth P. Harlow,Peter D. Beitsch,Pat Whitworth,Roger S. Foster,Kambiz Dowlatshahi +14 more
TL;DR: Biopsy of sentinel nodes can predict the presence or absence of axillary-node metastases in patients with breast cancer, however, the procedure can be technically challenging, and the success rate varies according to the surgeon and the characteristics of the patient.
Journal ArticleDOI
Phase II Trial of Intratumoral Administration of ONYX-015, a Replication-Selective Adenovirus, in Patients With Refractory Head and Neck Cancer
John Nemunaitis,Fadlo R. Khuri,Ian Ganly,James Arseneau,Mitchell C. Posner,Everett E. Vokes,Joseph A. Kuhn,Todd M. McCarty,S. Landers,A. Blackburn,Larry Romel,Britta Randlev,Stan B. Kaye,David H. Kirn +13 more
TL;DR: ONYX-015 can be safely administered via intratumoral injection to patients with recurrent/refractory SCCHN and evidence of modest antitumoral activity is suggested.
Journal Article
Selective Replication and Oncolysis in p53 Mutant Tumors with ONYX-015, an E1B-55kD Gene-deleted Adenovirus, in Patients with Advanced Head and Neck Cancer: A Phase II Trial
John Nemunaitis,Ian Ganly,Fadlo R. Khuri,James Arseneau,Joseph A. Kuhn,Todd M. McCarty,S. Landers,Phillip B. Maples,Larry Romel,Britta Randlev,Tony R. Reid,Sam Kaye,David H. Kirn +12 more
TL;DR: The first genetically engineered replication-competent virus to demonstrate selective intratumoral replication and necrosis in patients is demonstrated, demonstrating the promise of replication-selective viruses as a novel therapeutic platform against cancer.
Journal ArticleDOI
Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients.
John Nemunaitis,Casey Cunningham,Neil Senzer,Joseph A. Kuhn,Jennifer Cramm,Craig Litz,Robert Cavagnolo,Ann Cahill,Caroline Clairmont,Mario Sznol +9 more
TL;DR: The principle that a Salmonella bacterium can be utilized as a delivery vehicle of the cytosine deaminase gene to malignant tissue and that the delivered gene is functional is supported, at doses at or below 3 × 107 CFU/m2.
Journal ArticleDOI
Management of carotid body paragangliomas and review of a 30-year experience.
Peter Patetsios,Dennis Gable,Wilson V. Garrett,Jeffrey P. Lamont,Joseph A. Kuhn,William P. Shutze,Harry Kourlis,Bradley R. Grimsley,Gregory J. Pearl,Bertram L. Smith,C.M. Talkington,Jesse E. Thompson +11 more
TL;DR: It is demonstrated that early operative management is warranted to avoid the possibility of eventual metastasis and progressive local invasion to the point of inoperability in patients treated at this institution between 1971 and 2001.