Joseph B. Margolick

TL;DR: In this article, the authors studied the evolution of the C2-V5 region of the HIV-1 env gene and of T-cell subsets in nine men with a moderate or slow rate of disease progression.

TL;DR: Constant T-cell levels are confirmed in homosexual men with incident human immunodeficiency virus, type 1 (HIV-1), infection who remained free of acquired immunodficiency syndrome (AIDS) for up to eight years after seroconversion, suggesting that homeostasis failure is an important landmark in HIV disease progression.

TL;DR: The data indicate that cigarette smoking does not have a major effect on the progression of HIV-1 infection to AIDS or death but may affect the incidence of oral thrush.

TL;DR: Paired TCRβ-integration site analysis showed that infection could occur early or late in the course of a clone's response to antigen and could generate infected cell populations too large to be explained solely by homeostatic proliferation, implicate antigen-driven clonal selection as a major factor in HIV-1 persistence.

TL;DR: In this article, the authors assessed the association between T cell homeostasis and its failure and the occurence of AIDS and the switch from the non-syncytium-inducing (NSI) to the synthytiuminducing (SI) HIV virus phenotype.