J
Joseph G. Cory
Researcher at East Carolina University
Publications - 37
Citations - 1341
Joseph G. Cory is an academic researcher from East Carolina University. The author has contributed to research in topics: Ribonucleotide reductase & L1210 cells. The author has an hindex of 14, co-authored 37 publications receiving 1275 citations. Previous affiliations of Joseph G. Cory include Yale University.
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Journal ArticleDOI
5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazolyl)-3-(4-sulfophenyl)tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans As cell-viability indicators
TL;DR: Analogs of MTT, 3-(4,5-dimethylthiazolyl)-2,5diphenyltetrazolium bromide, designed to yield water-soluble formazans upon reduction, have been synthesized and evaluated as cell-viability indicators as mentioned in this paper.
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Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.
TL;DR: 3-AP is synthesized and demonstrated to have potent inhibition of L1210 leukemia cells in vitro, curative capacity for mice bearing the L 1210 leukemia, and sensitivity of HUr-resistant cells to 3-AP demonstrate the clinical potential of 3- AP as an antineoplastic agent.
Journal ArticleDOI
Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.
Joseph G. Cory,Ann H. Cory,Germana Rappa,Aurelio Lorico,Mao-Chin Liu,Tai-Shun Lin,Alan C. Sartorelli +6 more
TL;DR: The results obtained provide an experimental rationale for the further development of the HCTs, particularly 3-AP and 3-AMP, as potential drugs for clinical use in the treatment of cancer.
Journal Article
Critical roles of glutamine as nitrogen donors in purine and pyrimidine nucleotide synthesis: asparaginase treatment in childhood acute lymphoblastic leukemia.
Joseph G. Cory,Ann H. Cory +1 more
TL;DR: The specific roles of glutamine in the de novo synthesis of nucleotides are defined and an appropriate explanation for the cell cycle arrest and cytotoxicity induced in proliferating malignant lymphoblasts by asparaginase treatment is provided.
Journal ArticleDOI
Synthesis and Biological Activity of 3- and 5-Amino Derivatives of Pyridine-2-carboxaldehyde Thiosemicarbazone
TL;DR: A series of 3- and 5-alkylamino derivatives, as well as other structurally modified analogues of pyridine-2-carboxaldehyde thiosemicarbazone, have been synthesized and evaluated as inhibitors of CDP reductase activity and for their cytotoxicity in vitro and antineoplastic activity in vivo against the L1210 leukemia.