M.‐C. Liu

TL;DR: The findings demonstrate the superiority of Triapine over hydroxyurea as an anticancer agent and suggest that prevention byTriapine of repair of DNA lesions created by agents that damage DNA may result in efficacious drug combinations for the treatment of cancer.

TL;DR: 3-AP is synthesized and demonstrated to have potent inhibition of L1210 leukemia cells in vitro, curative capacity for mice bearing the L 1210 leukemia, and sensitivity of HUr-resistant cells to 3-AP demonstrate the clinical potential of 3- AP as an antineoplastic agent.

TL;DR: The most active compounds synthesized were 3-aminopyridine-2-carboxaldehyde thiosemicarbazone and 3-amino-4-methylpyridine,2- carboxaldehyde, thiosine-2,4-lutidine which produced against the L1210 leukemia and 40% 60-day long-term survivors at two daily doses of 40mg/kg and 10 mg/kg, respectively.

TL;DR: A series of 3- and 5-alkylamino derivatives, as well as other structurally modified analogues of pyridine-2-carboxaldehyde thiosemicarbazone, have been synthesized and evaluated as inhibitors of CDP reductase activity and for their cytotoxicity in vitro and antineoplastic activity in vivo against the L1210 leukemia.

TL;DR: The most active compounds synthesized were 4-aminoisoquinoline-1-carboxaldehyde thiosemicarbazone (9a) and 4-(methylamino)isoquinoline (9b), which both produced optimum % T/C values of 177 against the L1210 leukemia in mice when used at a daily dosage of 40 mg/kg for 6 consecutive days.