J
Joseph J. Schildkraut
Researcher at National Institutes of Health
Publications - 15
Citations - 5270
Joseph J. Schildkraut is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Reserpine & Imipramine. The author has an hindex of 11, co-authored 15 publications receiving 5142 citations.
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The catecholamine hypothesis of affective disorders: a review of supporting evidence
TL;DR: The "catecholamine hypothesis of affective disorders" as discussed by the authors suggests that depression is associated with an absolute or relative decrease in catecholamines, particularly norepinephrine, available at central adrenergic receptor sites.
Journal ArticleDOI
Biogenic Amines and Emotion
TL;DR: Although there does appear to be a fairly consistent relationship between the effects of pharmacological agents on norepinephrine metabolism and on affective state, a rigorous extrapolation from pharmacological studies to pathophysiology cannot be made, and confirmation of this hypothesis must ultimately depend upon direct demonstration of the biochemical abnormality in the naturally occurring illness.
Journal ArticleDOI
Metabolism of normetanephrine-H3 in rat brain--identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metabolite
TL;DR: It is suggested that deamination, reduction, and subsequent conjugation with sulfate is the primary route of metabolism of normetanephrine in rat brain and that norepinephrine is also metabolized to this sulfate conjugate.