J
Joseph L. Mann
Researcher at Stanford University
Publications - 21
Citations - 381
Joseph L. Mann is an academic researcher from Stanford University. The author has contributed to research in topics: Insulin & Self-healing hydrogels. The author has an hindex of 8, co-authored 18 publications receiving 207 citations.
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Journal ArticleDOI
Extreme Extensibility in Physically Cross-Linked Nanocomposite Hydrogels Leveraging Dynamic Polymer–Nanoparticle Interactions
Abigail K. Grosskopf,Joseph L. Mann,Julie Baillet,Hector Lopez Hernandez,Anton A. A. Autzen,Anthony C. Yu,Eric A. Appel +6 more
TL;DR: In this paper , a class of high water content nanocomposite hydrogel materials leveraging multivalent, noncovalent, polymer-nanoparticle (PNP) interactions between modified cellulose polymers and biodegradable nanoparticles is presented.
Posted ContentDOI
Engineering Insulin Cold Chain Resilience to Improve Global Access
Caitlin L. Maikawa,Joseph L. Mann,Aadithya Kannan,Catherine M. Meis,Ben S. Ou,Anton A. A. Smith,Anton A. A. Smith,Gerald G. Fuller,David M. Maahs,Eric A. Appel +9 more
TL;DR: These copolymers demonstrate promise as simple formulation additives to increase the cold chain resilience of commercial insulin formulations, thereby expanding global access to these critical drugs for treatment of diabetes.
Journal ArticleDOI
Stable High-Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient
John Klich,Catherine M. Kasse,Joseph L. Mann,Yaoqi Huang,Andrea I. d’Aquino,Abigail K. Grosskopf,Julie Baillet,Gerald G. Fuller,Eric A. Appel +8 more
TL;DR: In this paper , an amphiphilic copolymer excipient is proposed to enhance the stability of high-level formulations of clinically relevant monoclonal antibodies without altering their pharmacokinetics or injectability.
Posted ContentDOI
Injectable Nanoparticle-Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies
Santiago Correa,Emily C. Gale,Aaron T. Mayer,Xiao Z,Celine Liong,Klich Jh,Robert S. Brown,Emily L. Meany,Olivia M. Saouaf,Caitlin L. Maikawa,Abigail K. Grosskopf,Joseph L. Mann,Juliana Idoyaga,Eric A. Appel +13 more
TL;DR: In this paper, the ability of a slow-releasing injectable hydrogel depot to reduce the problematic dose-limiting toxicities of immunostimulatory CD40 agonist antibodies (CD40a) while maintaining their potent anti-cancer efficacy was explored.
Posted ContentDOI
Ultra-fast insulin-pramlintide co-formulation for improved glucose management in diabetic rats
Caitlin L. Maikawa,Peyton C. Chen,Eric T. Vuong,Leslee T. Nguyen,Joseph L. Mann,Andrea I. d’Aquino,Rayhan A. Lal,David M. Maahs,Bruce A. Buckingham,Eric A. Appel +9 more
TL;DR: In this article, a stable co-formulation of monomeric insulin and amylin analogues (lispro and pramlintide) with synchronous pharmacokinetics and ultra-rapid action is presented.