Joseph N. Marcus

TL;DR: Immunohistochemically detected p53 protein accumulation was an independent marker of shortened survival and was seen more often in familial than in sporadic carcinomas, suggesting a correlation between p53protein accumulation and p53 gene mutation.

TL;DR: The purpose of this investigation was to determine if there are pathobiologic differences between BRCA1‐related and BRCa2‐related hereditary breast cancer (HBC) and non‐HBC.

TL;DR: Clinically, bile diversion by suprapapillary Roux-en-Yduodenojejunostomy alleviates symptoms of duodenogastric reflux disease without being ulcerogenic (in the presence of normal gastric secretion) or prolonging gastric emptying.

TL;DR: It is recommended that the family history of all patients with a newly diagnosed colon cancer be evaluated for evidence of the hereditary nonpolyposis syndromes syndrome, and a subtotal abdominal colectomy is indicated at the time of the initial colon cancer because of the risk of synchronous and metachronous lesions.

TL;DR: Clinician must recognize clinical findings and family history typical of HNPCC, and third-party carriers must become more responsive to the costly surveillance measures required for otherwise healthy patients.