J
Joseph R. Delaney
Researcher at Massachusetts Institute of Technology
Publications - 3
Citations - 773
Joseph R. Delaney is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: T-cell receptor & CD8. The author has an hindex of 3, co-authored 3 publications receiving 771 citations.
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Journal ArticleDOI
Evidence for a differential avidity model of T cell selection in the thymus
Philip G. Ashton-Rickardt,Antonio Bandeira,Joseph R. Delaney,Luc Van Kaer,Hanspeter Pircher,Rolf M. Zinkernagel,Susumu Tonegawa +6 more
TL;DR: A critical parameter that controls the fate of a thymocyte seems to be the number of TCRs engaged with complexes of peptide and major histocompatibility complex and when this number is low, positive selection occurs, and when it is high, negative selection takes place.
Journal ArticleDOI
Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection
TL;DR: The results suggest that quantitative differences in the level of expression of class I MHC proteins on thymic epithelial and dendritic cells contribute to the opposing roles these cells play in forming the repertoire of mature classI MHC restricted (CD8+) T cells.
Journal ArticleDOI
A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects.
Markus G. Rudolph,Lucy Q. Shen,Stephen A. Lamontagne,John G. Luz,Joseph R. Delaney,Qing Ge,Bryan K. Cho,Deborah Palliser,Carol A. McKinley,Jianzhu Chen,Ian A. Wilson,Herman N. Eisen +11 more
TL;DR: The crystal structure and the activities of alanine-substituted peptide variants point to the properties of the peptide P4 side chain and the conformation of the Tyr-P6 side chain as the structural determinants of GNYSFYAL antagonist activity.