H
Hanspeter Pircher
Researcher at University of Freiburg
Publications - 163
Citations - 17471
Hanspeter Pircher is an academic researcher from University of Freiburg. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 65, co-authored 161 publications receiving 16755 citations. Previous affiliations of Hanspeter Pircher include Novartis & University of Zurich.
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Journal ArticleDOI
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice.
Pamela S. Ohashi,Stephan Oehen,Kurt Buerki,Hanspeter Pircher,Cara T. Ohashi,Bernhard Odermatt,Bernard Malissen,Rolf M. Zinkernagel,Hans Hengartner +8 more
TL;DR: This model indicates that self-reactive cytotoxic T cells may remain functionally unresponsive, owing to a lack of appropriate T cell activation, in so-called "T cell-mediated autoimmune diseases".
Journal ArticleDOI
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
TL;DR: The results illustrate that partially and sequen-tially induced (protective) immunity or complete exhaustion of T-cell immunity (high zone tolerance) are quantitatively different points on the scale of immunity; some viruses exploit the latter possibility to persist in an immunocompetent host.
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Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
TL;DR: T-cell tolerance in transgenic mice expressing a T-cell receptor with double specificities for lymphocytic choriomeningitis virus (LCMV)-H-2Db and for the mixed-lymphocyte stimulatory (Mlsa) antigen is studied.
Journal ArticleDOI
Evidence for a differential avidity model of T cell selection in the thymus
Philip G. Ashton-Rickardt,Antonio Bandeira,Joseph R. Delaney,Luc Van Kaer,Hanspeter Pircher,Rolf M. Zinkernagel,Susumu Tonegawa +6 more
TL;DR: A critical parameter that controls the fate of a thymocyte seems to be the number of TCRs engaged with complexes of peptide and major histocompatibility complex and when this number is low, positive selection occurs, and when it is high, negative selection takes place.
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CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset
Sandra López-Vergès,Jeffrey M. Milush,Suchitra Pandey,Vanessa A. York,Janice Arakawa-Hoyt,Hanspeter Pircher,Phillip J. Norris,Phillip J. Norris,Douglas F. Nixon,Lewis L. Lanier +9 more
TL;DR: A combination of a mature phenotype, a higher cytotoxic capacity, aHigher sensitivity to stimulation via CD16, with a decreased responsiveness to cytokines, and a decreased capacity to proliferate suggest that CD57(+) NK cells are highly mature and might be terminally differentiated.