J
Joseph T. Morott
Researcher at University of Mississippi
Publications - 19
Citations - 819
Joseph T. Morott is an academic researcher from University of Mississippi. The author has contributed to research in topics: Extrusion & Solubility. The author has an hindex of 14, co-authored 19 publications receiving 682 citations.
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Journal ArticleDOI
Melt extrusion: process to product
Michael A. Repka,Sejal Shah,Jiannan Lu,Sindhuri Maddineni,Joseph T. Morott,Ketaki Patwardhan,Noorullah Naqvi Mohammed +6 more
TL;DR: This review provides a holistic perspective on HME from equipment, processing and materials to its varied applications in oral delivery, as well as trans-drug delivery, oral mucosal, dermal, ungual and intravaginal systems.
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A novel floating controlled release drug delivery system prepared by hot-melt extrusion.
Anh Q. Vo,Xin Feng,Joseph T. Morott,Manjeet B. Pimparade,Roshan V. Tiwari,Feng Zhang,Michael A. Repka +6 more
TL;DR: All formulations showed zero lag time and excellent floating strength, indicating immediate-floating pellet formation, and understanding the variables' effects on the formulations allows for the tailoring of this delivery system to obtain various drug release profiles.
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Stability-enhanced hot-melt extruded amorphous solid dispersions via combinations of Soluplus® and HPMCAS-HF.
Saad M. Alshahrani,Wenli Lu,Jun-Bom Park,Joseph T. Morott,Bader B. Alsulays,Soumyajit Majumdar,Nigel Langley,Karl Kolter,Andreas Gryczke,Michael A. Repka +9 more
TL;DR: A novel combination of Soluplus and hypromellose acetate succinate (HPMCAS-HF) polymers for solubility enhancement as well as enhanced physicochemical stability of the produced amorphous solid dispersions was evaluated.
Journal ArticleDOI
Development and evaluation of an oral fast disintegrating anti-allergic film using hot-melt extrusion technology
Manjeet B. Pimparade,Anh Q. Vo,Abhijeet Maurya,Jungeun Bae,Joseph T. Morott,Xin Feng,Dong Wuk Kim,Vijay I. Kulkarni,Roshan V. Tiwari,K. Vanaja,Reena Murthy,H.N. Shivakumar,D. Neupane,Sanjay R. Mishra,S. N. Murthy,Michael A. Repka +15 more
TL;DR: The main objective of this novel study was to develop chlorpheniramine maleate orally disintegrating films (ODF) using hot‐melt extrusion technology and evaluate the characteristics of the formulation using in vitro and in vivo methods.
Journal ArticleDOI
Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology.
Jun-Bom Park,Suneela Prodduturi,Joseph T. Morott,Vijay I. Kulkarni,Melissa R. Jacob,Shabana I. Khan,Steven P Stodghill,Michael A. Repka +7 more
TL;DR: The ADA system, containing blends of HPC and PEO, enhanced the effectiveness of the antimicrobials a maximum of fivefold toward the inhibition of cell adherence of Candida albicans to mammalian cells/Vero cells.