Melissa R. Jacob

TL;DR: A beneficial effect from the daily intake of POMx and pomegranate juice (PJ) as dietary supplements to augment the human immune system's antioxidant, antimalarial and antimicrobial capacities is suggested.

TL;DR: Results support a role of Mg(2+) ion binding in the selective cytotoxicity of UK-1 and provide a minimal pharmacophore for the select cytotoxic activity of the natural product.

TL;DR: The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains, suggesting that the C-27 steroidal Saponins may be considered potential antIFungal leads for further preclinical study.

TL;DR: Genes with the greatest specificity for a particular drug were grouped together as drug-specific genes, whereas genes with a lack of drug specificity were also identified and shed new light on the mechanisms of action of these classes of antifungal agents.

TL;DR: Results of promising antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.