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Nigel Langley
Researcher at BASF SE
Publications - 15
Citations - 444
Nigel Langley is an academic researcher from BASF SE. The author has contributed to research in topics: Solubility & Extrusion. The author has an hindex of 9, co-authored 14 publications receiving 346 citations.
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Journal ArticleDOI
The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus®-based solid dispersions.
TL;DR: Investigation of the ability of inorganic salts to improve the dissolution rate of carbamazepine from tablets containing a high loading of a Soluplus®-based solid dispersion demonstrated the utility of including salts in tablets to improve dissolution properties.
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Stability-enhanced hot-melt extruded amorphous solid dispersions via combinations of Soluplus® and HPMCAS-HF.
Saad M. Alshahrani,Wenli Lu,Jun-Bom Park,Joseph T. Morott,Bader B. Alsulays,Soumyajit Majumdar,Nigel Langley,Karl Kolter,Andreas Gryczke,Michael A. Repka +9 more
TL;DR: A novel combination of Soluplus and hypromellose acetate succinate (HPMCAS-HF) polymers for solubility enhancement as well as enhanced physicochemical stability of the produced amorphous solid dispersions was evaluated.
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Conjugation of Hot-Melt Extrusion with High-Pressure Homogenization: a Novel Method of Continuously Preparing Nanocrystal Solid Dispersions
Xingyou Ye,Hemlata Patil,Xin Feng,Roshan V. Tiwari,Jiannan Lu,Jiannan Lu,Andreas Gryczke,Karl Kolter,Nigel Langley,Soumyajit Majumdar,D. Neupane,Sanjay R. Mishra,Michael A. Repka +12 more
TL;DR: The conjugation of HPH with HME technology was demonstrated to be a promising novel method for the production of NCSDs, which was found to be highly stable after storage for 6 months.
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Hot melt extrusion as an approach to improve solubility, permeability and oral absorption of a psychoactive natural product, piperine.
Eman A. Ashour,Soumyajit Majumdar,Abdulla Alsheteli,Sultan Alshehri,Bader B. Alsulays,Xin Feng,Andreas Gryczke,Karl Kolter,Nigel Langley,Michael A. Repka +9 more
TL;DR: The aims of the current research project were to investigate the efficiency of various polymers to enhance the solubility and increase the systemic absorption of piperine using hot melt extrusion technology.
Journal ArticleDOI
Solid-state characterization of Felodipine–Soluplus amorphous solid dispersions
Jiannan Lu,Kristina A. Cuellar,Nathan I. Hammer,Seongbong Jo,Andreas Gryczke,Karl Kolter,Nigel Langley,Michael A. Repka +7 more
TL;DR: Amorphous solid dispersion via hot melt extrusion technology to improve the solubility of a water-insoluble compound, felodipine, was enhanced while a homogeneous SD was achieved for 10% drug loading.