J
Joseph Wagner
Researcher at Marion Merrell Dow
Publications - 49
Citations - 1746
Joseph Wagner is an academic researcher from Marion Merrell Dow. The author has contributed to research in topics: Aromatic L-amino acid decarboxylase & Putrescine. The author has an hindex of 23, co-authored 49 publications receiving 1730 citations.
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Simultaneous Determination of 3,4-Dihydroxyphenylalanine, 5-Hydroxytryptophan, Dopamine, 4-Hydroxy-3-Methoxyphenylalanine, Norepinephrine, 3,4-Dihydroxyphenylacetic Acid, Homovanillic Acid, Serotonin, and 5-Hydroxyindoleacetic Acid in Rat Cerebrospinal Fluid and Brain by High-Performance Liquid Chromatography with Electrochemical Detection
TL;DR: A method using reversed‐phase ion‐pair high‐performance liquid chromatography with electrochemical detection for the simultaneous determination of tryptophan (TRP), 3,4‐dihydroxyphenylalanine (DOPA), and their metabolites in whole brain, small‐brain parts, and cerebrospinal fluid of rats has been developed.
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Determination of DOPA, dopamine, DOPAC, epinephrine, norepinephrine, α-monofluoromethyldopa and α-difluoromethyldopa in various tissues of mice and rats using reversed-phase ion-pair liquid chromatography with electrochemical detection☆
TL;DR: A semi-automated procedure making use of an automatic sample processor and a digital integrator permitted the analysis of as many as sixty samples per day to be applied to the determination of catechols in other organs such as prostates and seminal vesicles of rats and in smaller tissues like mesenteric arteries.
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A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease.
Elaine A. Mackay,A. Ehrhard,Marc Moniatte,Chantal Guenet,Chantal Tardif,Céline Tarnus,Odile Sorokine,Blanche Heintzelmann,Carole Nay,J.M. Remy,Jeffrey N. Higaki,Alain Van Dorsselaer,Joseph Wagner,Charles Danzin,Pierre S. Mamont +14 more
TL;DR: Formation of the 4-kDa peptides, which are essential constituents of the extracellular plaques in Alzheimer's disease, involves the sequential cleavage of the amyloid precursor protein (APP) by beta- and gamma-secretases.
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Accumulation of decarboxylated S-adenosyl-L-methionine in mammalian cells as a consequence of the inhibition of putrescine biosynthesis.
Pierre S. Mamont,Charles Danzin,Joseph Wagner,Mirlyse Siat,Anne-Marie Joder-Ohlenbusch,Nicole Claverie +5 more
TL;DR: Altering of polyamine synthesis by DL-alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of L-ornithines decarboxylase, leads to a striking accumulation of decar boxylated S-adenosyl-L-methionine in rat hepatoma cells cultured in vitro and in rat ventral prostate.
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Reversed-phase ion-pair liquid chromatographic procedure for the simultaneous analysis of S-adenosylmethionine, its metabolites and the natural polyamines.
TL;DR: A method using reversed-phase ion-pair liquid chromatography with dual detection was developed for the simultaneous determination of the S-adenosylmethionine (SAM) analogues and the natural polyamines in one single run by direct injection of tissue extracts.