J
Josip Madunić
Researcher at University of Zagreb
Publications - 16
Citations - 494
Josip Madunić is an academic researcher from University of Zagreb. The author has contributed to research in topics: Gene expression & MTT assay. The author has an hindex of 7, co-authored 16 publications receiving 322 citations.
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Apigenin: A dietary flavonoid with diverse anticancer properties.
TL;DR: Based on the available literature, the beneficial effects of apigenin as a future anticancer modality are promising but they require further in vitro and in-vivo studies to enable its translation from bench to bedside.
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Melittin induced cytogenetic damage, oxidative stress and changes in gene expression in human peripheral blood lymphocytes.
Goran Gajski,Ana-Marija Domijan,Bojana Žegura,Alja Štern,Marko Gerić,Ivana Novak Jovanović,Ivana Vrhovac,Josip Madunić,Davorka Breljak,Metka Filipič,Vera Garaj-Vrhovac +10 more
TL;DR: It is found that MEL was cytotoxic for HPBLs in a dose- and time-dependent manner and evidence that oxidative stress is involved in its DNA damaging effects is provided.
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Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells
Ivana Vrhovac Madunić,Josip Madunić,Maja Antunović,Mladen Paradžik,Vera Garaj-Vrhovac,Davorka Breljak,Inga Marijanović,Goran Gajski +7 more
TL;DR: The observed cytogenotoxic and pro-cell death activities of apigenin coupled with its low toxicity towards normal cells indicate that this natural product could be used as a future anticancer modality.
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The Urokinase Plasminogen Activator System in Human Cancers: An Overview of Its Prognostic and Predictive Role
TL;DR: This review focuses on uPA system's prognostic and predictive role in several types of human cancers, summarizing its activities in cancer development and highlighting the importance of addressing all unanswered questions before bridging the gap between laboratory findings to clinic use of the system's components as cancer biomarkers.
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Antagonistic and synergistic epigenetic modulation using orthologous CRISPR/dCas9-based modular system
Goran Josipović,Vanja Tadić,Marija Klasić,Vladimir Zanki,Ivona Bečeheli,Felicia Fei-Lei Chung,Akram Ghantous,Toma Keser,Josip Madunić,Maria Bošković,Gordan Lauc,Zdenko Herceg,Aleksandar Vojta,Vlatka Zoldoš +13 more
TL;DR: A modular and extensible CRISPR/dCas9-based toolbox for epigenetic editing and direct gene regulation is presented and strong and persistent synergistic effect on gene transcription is revealed, up to 30 days following cell transfection, suggesting involvement of epigenetic mechanisms in maintenance of the reactivated state.