Ivona Bečeheli

TL;DR: This study has revealed very extensive and complex changes in IgG glycosylation with age, and the combined index composed of only three glycans explained up to 58% of variance in age, considerably more than other biomarkers of age like telomere lengths.

TL;DR: Recent progress in high-throughput glycomics, genomics and epigenomics enabled first epidemiological and genome-wide association studies of the glycome, which are presented in this mini-review.

TL;DR: A modular and extensible CRISPR/dCas9-based toolbox for epigenetic editing and direct gene regulation is presented and strong and persistent synergistic effect on gene transcription is revealed, up to 30 days following cell transfection, suggesting involvement of epigenetic mechanisms in maintenance of the reactivated state.

TL;DR: The meta-analysis indicates a role of the RASSF1A promoter hypermethylation from peripheral blood in TCGT, and that finding was confirmed in a cohort study, which represents the first report of changed RassF 1A promoter methylation in peripheral blood TGCT.

TL;DR: The obtained results suggest that HTR2A is a sexually dimorphic epigenetic target of intrauterine exposures and may contribute to a better understanding of the early developmental origins of neurobehavioral and metabolic disorders associated with altered H TR2A function.