Josune García-Sanmartín

TL;DR: AM is a great target for drug development and new drugs interfering with this system are being developed since AM acts as an autocrine/paracrine growth factor, increases tumour cell motility and metastasis, induces angiogenesis, and blocks immunosurveillance by inhibiting the immune system.

TL;DR: Application of the bilayered dressing in the wound healing rabbit ear model shows an improved cicatrization of the wound in both ischemic and non-ischemic defects, favoring epithelialization and reducing noticeably the contraction and the inflammation.

TL;DR: A new series of MMP2 inhibitors is described, following a fragment-based drug design approach, and one fragment containing an azide group and a well known hydroxamate Zinc Binding Group in a α-sulfone, α-tetrahydropyrane scaffold has been synthesized.

TL;DR: In this paper, the authors explored the behavior of calcitonin gene-related peptide (CGRP), an angiogenic, vasodilating, and immune modulating peptide, in severe acute respiratory syndrome coronavirus 2 positive patients.

TL;DR: It is suggested that treatment with AM or with positive modulator SMs may represent a novel strategy for colon cancer.