József Tímár

TL;DR: RAS mutation is the most frequent oncogenic alteration in human cancers, followed by NRAS, and KRAS mutant cancers are characterized by typical, cancer-type-specific co-occurring mutations and distinct gene expression signatures.

TL;DR: A pixel-by-pixel tissue identification method was developed, featuring the PCA/LDA analysis of authentic data set, and localization of unknowns in the resulting 60D, histologically assigned LDA space, which resulted in results which are in 95% agreement with the results of classical histology.

TL;DR: It is demonstrated that the cancer cells studied do not defer proliferation for migration, in line with the observation of pathologists that highly proliferative tumors are often highly invasive.

TL;DR: An online analysis tool to compute ER and HER2 status, Oncotype DX 21-gene recurrence score and an independent recurrence risk classification using gene expression data obtained by interrogation of Affymetrix microarray profiles and to provide a global tool for the online determination of different prognostic parameters simultaneously using genome-wide microarrays is developed.

TL;DR: It is found that increased EGFR protein levels and gene copy numbers (not gene amplification alone) have prognostic significance in the investigated HNSCC patient population, however, the relatively high incidence of the EGFR-vIII mutant form warrants careful therapeutic decision-making when choosing between different anti-EGFR treatment options.