Showing papers by "Juan A. Squella published in 1979"
TL;DR: A new polarographic method is used for quantitative analysis of ampicillin dosage forms, which has a major advantage is the selectivity, which makes the determination ofAmpicillin possible without prior separation of the excipient.
16 citations
TL;DR: A polarographic method has been developed for the quantitative analysis of cephradine and its dosage forms and the precise chemical identity of the electroactive product has not been determined, but UV spectral data and the TLC Rf value are reported.
Abstract: A polarographic method has been developed for the quantitative analysis of cephradine and its dosage forms. Direct determinations on capsules are carried out; excipients and coloring matter do not interfere in the determination. The electroactive product is formed by acidic hydrolysis with 5.0N HCl and heating at 80 degrees C for 60 min. Two polarographic waves are obtained: I = -0.46 V and II = -0.78 v vs. SCE. Both reduction waves are diffusion controlled. Wave I is preferred for analytical purposes. The precise chemical identity of the electroactive product has not been determined, but UV spectral data and the TLC Rf value are reported. A linear relation is established for levels of cephradine between 10(-2) and 10(-5)M in 5.0N HCl.
4 citations