Juan Chen

TL;DR: The successful production of live cloned, reproductively competent, ferrets using species-specific SCNT methodologies is reported, making it feasible to begin generating genetically defined ferrets for studying transmissible and inherited human lung diseases.

TL;DR: This study describes the production of a CFTR gene-deficient model in the domestic ferret using recombinant adeno-associated virus-mediated gene targeting in fibroblasts, followed by nuclear transfer cloning.

TL;DR: The results from clinical studies suggest that inhibitors targeting the Wnt pathway show promise against lung cancer, and the regulatory roles of microRNAs in Wnt signaling are expounded, as well as the potential of the WNT pathway to provide biomarkers and therapeutic targets in lung cancer.

TL;DR: This minireview aims for the development of noninvasive biomarkers and novel therapeutic approaches for cancer based on Nrf2-directed cancer metabolic reprogramming in the near future and to highlight the role of NRF2 in the regulation of malignant transformation, cancer proliferation, and theDevelopment of treatment resistance via metabolic adaptations.

TL;DR: It is suggested that increased expression of miR‐641 significantly contributes to erlotinib resistance development in NSCLC cells through activating ERK signaling by targeting NF1 and that inhibition of mi R‐641 may reverse acquired resistance of NS CLC cells to erotinib treatment.