抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

http://www.maths.qmul.ac.uk/%7Elatora/report_06.pdf

Complex networks: Structure and dynamics

N G van Kampen 1981 Amsterdam: North-Holland xiv + 419 pp price Dfl 180 This is a book which, at a lower price, could be expected to become an essential part of the library of every physical scientist concerned with problems involving fluctuations and stochastic processes, as well as those who just enjoy a beautifully written book. It provides an extensive graduate-level introduction which is clear, cautious, interesting and readable.

https://iopscience.iop.org/article/10.1088/0031-9112/34/4/040/pdf

Stochastic Processes in Physics and Chemistry

1980 Preface * 1999 Preface * 1999 Acknowledgements * Introduction * 1 Circular Logic * 2 Phase Singularities (Screwy Results of Circular Logic) * 3 The Rules of the Ring * 4 Ring Populations * 5 Getting Off the Ring * 6 Attracting Cycles and Isochrons * 7 Measuring the Trajectories of a Circadian Clock * 8 Populations of Attractor Cycle Oscillators * 9 Excitable Kinetics and Excitable Media * 10 The Varieties of Phaseless Experience: In Which the Geometrical Orderliness of Rhythmic Organization Breaks Down in Diverse Ways * 11 The Firefly Machine 12 Energy Metabolism in Cells * 13 The Malonic Acid Reagent ('Sodium Geometrate') * 14 Electrical Rhythmicity and Excitability in Cell Membranes * 15 The Aggregation of Slime Mold Amoebae * 16 Numerical Organizing Centers * 17 Electrical Singular Filaments in the Heart Wall * 18 Pattern Formation in the Fungi * 19 Circadian Rhythms in General * 20 The Circadian Clocks of Insect Eclosion * 21 The Flower of Kalanchoe * 22 The Cell Mitotic Cycle * 23 The Female Cycle * References * Index of Names * Index of Subjects

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/596B270197FE27DE5FABB598B6210622/S0025557200150892a.pdf/div-class-title-span-class-italic-the-geometry-of-biological-time-span-by-a-t-winfree-pp-544-dm68-corrected-second-printing-1990-isbn-3-540-52528-9-springer-div.pdf

The geometry of biological time , by A. T. Winfree. Pp 544. DM68. Corrected Second Printing 1990. ISBN 3-540-52528-9 (Springer)

https://deim.urv.cat/~alexandre.arenas/publicacions/pdf/review.pdf

Synchronization in complex networks

Calsequestrin-Mediated Mechanism for Cellular Calcium Transient Alternans

We study the emergence of collective synchronization in large directed networks of heterogeneous oscillators by generalizing the classical Kuramoto model of globally coupled phase oscillators to more realistic networks We extend recent theoretical approximations describing the transition to synchronization in large undirected networks of coupled phase oscillators to the case of directed networks We also consider the case of networks with mixed positive-negative coupling strengths We compare our theory with numerical simulations and find good agreement

/pdf/synchronization-in-large-directed-networks-of-coupled-phase-2mpna9fmu4.pdf

Synchronization in large directed networks of coupled phase oscillators

Inhibiting nodes in dynamical complex networks leads to self-sustaining excitations, rather than a suppression of activity

/pdf/inhibition-causes-ceaseless-dynamics-in-networks-of-3avhxrt4e9.pdf

Inhibition causes ceaseless dynamics in networks of excitable nodes.

In this paper, we analyze the signal-to-interference-plus-noise ratio (SINR) performance at a mobile station (MS) in a random cellular network. The cellular network is formed by base stations (BSs) placed in a one-, two-, or three-dimensional space according to a possibly non-homogeneous Poisson point process, which is a generalization of the so-called shotgun cellular system. We develop a sequence of equivalence relations for the SCSs and use them to derive semi-analytical expressions for the coverage probability at the MS when the transmissions from each BS may be affected by random fading with arbitrary distributions as well as attenuation following arbitrary path-loss models. For homogeneous Poisson point processes in the interference-limited case with power-law path-loss model, we show that the SINR distribution is the same for all fading distributions and is not a function of the base station density. In addition, the influence of random transmission power, power control, and multiple channel reuse groups on the downlink performance is also discussed. The techniques developed for the analysis of SINR have applications beyond cellular networks and can be used in similar studies for cognitive radio networks, femtocell networks, and other heterogeneous and multi-tier networks.

Downlink Performance Analysis for a Generalized Shotgun Cellular System

We study synchronization of sinusoidally coupled phase oscillators on networks with modular structure and a large number of oscillators in each community. Of particular interest is the hierarchy of local and global synchrony, i.e., synchrony within and between communities, respectively. Using the recent ansatz of Ott and Antonsen [Chaos 18, 037113 (2008)], we find that the degree of local synchrony can be determined from a set of coupled low-dimensional equations. If the number of communities in the network is large, a low-dimensional description of global synchrony can be also found. Using these results, we study bifurcations between different types of synchrony. We find that, depending on the relative strength of local and global coupling, the transition to synchrony in the network can be mediated by local or global effects.

Juan G. Restrepo

Papers

Calsequestrin-Mediated Mechanism for Cellular Calcium Transient Alternans

Synchronization in large directed networks of coupled phase oscillators

Inhibition causes ceaseless dynamics in networks of excitable nodes.

Downlink Performance Analysis for a Generalized Shotgun Cellular System

Hierarchical synchrony of phase oscillators in modular networks.