J
Juan M. Benito
Researcher at University of Seville
Publications - 100
Citations - 3310
Juan M. Benito is an academic researcher from University of Seville. The author has contributed to research in topics: Gene delivery & Cyclodextrin. The author has an hindex of 29, co-authored 96 publications receiving 2989 citations. Previous affiliations of Juan M. Benito include Joseph Fourier University & Carlsberg Laboratory.
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Cyclodextrin-based gene delivery systems
TL;DR: This critical review provides an overview of different strategies to promote interactions between CD conjugates and genetic material by fully exploiting the inside-outside/upper-lower face anisotropy of the CD nanometric platform.
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Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis.
TL;DR: Protein persulfidation in the Arabidopsis proteome is widespread and is the molecular mechanism by which hydrogen sulfide performs its signaling role.
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Optimizing saccharide-directed molecular delivery to biological receptors: design, synthesis, and biological evaluation of glycodendrimer-cyclodextrin conjugates.
Juan M. Benito,Marta Gómez-García,Carmen Ortiz Mellet,Isabelle Baussanne,Jacques Defaye,José M. García Fernández +5 more
TL;DR: The results confirm the high drug solubilization capability of this new type of betaCD-dendrimer construct and indicate that subtle changes in the architecture of the conjugate may have important consequences on receptor affinity.
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Probing secondary carbohydrate-protein interactions with highly dense cyclodextrin-centered heteroglycoclusters: the heterocluster effect.
Marta Gómez-García,Juan M. Benito,David Rodríguez-Lucena,Jian-Xin Yu,Kazimierz Chmurski,Carmen Ortiz Mellet,Ricardo Gutierrez Gallego,Alfredo Maestre,Jacques Defaye,José M. García Fernández +9 more
TL;DR: Comparison of the lectin-binding properties for highly dense beta-cyclodextrin-centered homo- and heteroglycoclusters with defined architecture provides evidence for the existence of strong synergic effects (heterocluster effect) on carbohydrate-protein recognition events.
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Pharmacological chaperone therapy for Gaucher disease: a patent review.
TL;DR: This review summarizes the different approaches used to implement the concept of pharmacological chaperone therapy (PCT) for GD and discusses the relevant research, patents and patent applications filed in the last decade.