J
Juan Ortín
Researcher at Spanish National Research Council
Publications - 103
Citations - 9936
Juan Ortín is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Virus & RNA. The author has an hindex of 53, co-authored 103 publications receiving 9551 citations. Previous affiliations of Juan Ortín include Carlos III Health Institute.
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Journal ArticleDOI
Splicing of influenza virus matrix protein mRNA expressed from a simian virus 40 recombinant.
TL;DR: Different intranuclear distribution of segment 7 transcripts was found in each type of infected cell, and it is speculated that these differences in splicing efficiency and splice site choice might be related to different subnuclear localizations of segments 7 transcripts synthesized by the different transcriptional machineries.
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Apoptosis, toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
Isidoro Martínez,Juan Carlos Oliveros,Isabel Cuesta,Jorge Barrera,Vicente Ausina,Vicente Ausina,Cristina Casals,Cristina Casals,Alba de Lorenzo,Alba de Lorenzo,Ernesto García,Ernesto García,Belén García-Fojeda,Belén García-Fojeda,Junkal Garmendia,Junkal Garmendia,Mar González-Nicolau,Alicia Lacoma,Alicia Lacoma,Margarita Menéndez,Margarita Menéndez,David Moranta,Amelia Nieto,Amelia Nieto,Juan Ortín,Juan Ortín,Alicia Pérez-González,Alicia Pérez-González,Cristina Prat,Cristina Prat,Elisa Ramos-Sevillano,Elisa Ramos-Sevillano,Verónica Regueiro,Ariel Rodriguez-Frandsen,Ariel Rodriguez-Frandsen,Dolores Solís,Dolores Solís,Jose Yuste,Jose Yuste,José A. Bengoechea,José A. Melero +40 more
TL;DR: Alveolar macrophages were independently infected with three unrelated bacterial and two dissimilar viral respiratory pathogens and patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis, identifying new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.
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Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition
TL;DR: It is shown that influenza virus downregulates the unfolded protein response mediated by the PERK sensor, while Montelukast, a drug used to treat asthma in humans, specifically stimulated this response and downregulated viral protein synthesis and multiplication.
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Human Staufen1 associates to miRNAs involved in neuronal cell differentiation and is required for correct dendritic formation.
TL;DR: It is shown that human Staufen1-containing complexes contain essential elements of the gene silencing apparatus, like Ago1-3 proteins, and a set of miRNAs specifically associated to complexes containing human StAUfen1 are described.
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Kidney histopathological findings in fatal pandemic 2009 influenza A (H1N1).
Nicolás Nin,José A. Lorente,Carolina Sánchez-Rodríguez,Rosario Granados,Lorena S. Ver,Lorena S. Ver,Luis Soto,Jefferson Hidalgo,P. Fernández-Segoviano,Juan Ortín,Juan Ortín,Andrés Esteban +11 more
TL;DR: In this article, the specific kidney cell type targeted by pandemic 2009 influenza A (H1N1) virus infection was revealed by staining with 4',6-diamidino-2phenylindole (DAPI).