J
José A. Melero
Researcher at Carlos III Health Institute
Publications - 128
Citations - 7890
José A. Melero is an academic researcher from Carlos III Health Institute. The author has contributed to research in topics: Virus & Epitope. The author has an hindex of 48, co-authored 128 publications receiving 7198 citations. Previous affiliations of José A. Melero include Autonomous University of Madrid & Ablynx.
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Journal ArticleDOI
Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease
Maria Florencia Delgado,Silvina Coviello,A. Clara Monsalvo,Guillermina A. Melendi,Johanna Zea Hernandez,Juan P. Batalle,Leandro Diaz,Alfonsina Trento,Herng Yu Chang,Wayne Mitzner,Jeffrey V. Ravetch,José A. Melero,Pablo M. Irusta,Fernando P. Polack +13 more
TL;DR: It is shown that inactivated RSV vaccines may be rendered safe and effective by inclusion of TLR agonists in their formulation, and affinity maturation is identified as a key factor for the safe immunization of infants.
Journal ArticleDOI
Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years.
Peter L. Collins,José A. Melero +1 more
TL;DR: RSV is notable for a historic, tragic pediatric vaccine failure involving a formalin-inactivated virus preparation that was evaluated in the 1960s and that was poorly protective and paradoxically primed for enhanced RSV disease.
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The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.
Natalie I Mazur,Deborah Higgins,Marta C. Nunes,José A. Melero,Annefleur C Langedijk,Nicole Horsley,Ursula J. Buchholz,Peter J. M. Openshaw,Jason S. McLellan,Janet A. Englund,Asuncion Mejias,Ruth A. Karron,Eric A. F. Simões,Ivana Knezevic,Octavio Ramilo,Pedro A Piedra,Helen Y. Chu,Ann R. Falsey,Harish Nair,Leyla Kragten-Tabatabaie,Anne Greenough,Eugenio Baraldi,Nikolaos G. Papadopoulos,Johan Vekemans,Fernando P. Polack,Mair Powell,Ashish Satav,Edward E. Walsh,Renato T. Stein,Barney S. Graham,Louis Bont +30 more
TL;DR: This Review provides a comprehensive overview of RSV vaccine candidates and mAbs in clinical development to prevent one of the most common and severe infectious diseases in young children and older adults worldwide.
Journal ArticleDOI
Correction: Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
Iebe Rossey,Morgan S.A. Gilman,Stephanie C. Kabeche,Koen Sedeyn,Daniel Wrapp,Masaru Kanekiyo,Man Chen,Vicente Mas,Jan Spitaels,José A. Melero,Barney S. Graham,Bert Schepens,Jason S. McLellan,Xavier Saelens +13 more
TL;DR: This corrects the article DOI: 10.1038/ncomms14158 to indicate that the author of the paper is a doctor rather than a scientist, as previously reported.
Journal ArticleDOI
Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion.
Luis González-Reyes,M B Ruiz-Argüello,Blanca García-Barreno,L. J. Calder,Juan Antonio López,Juan Pablo Albar,John J. Skehel,Don C. Wiley,José A. Melero +8 more
TL;DR: Site-directed mutagenesis indicates that processing of F0 protein involves independent cleavage at both sites, and both cleavages are required for the F protein to be active in membrane fusion as judged by syncytia formation.