J
Juan Pablo Couso
Researcher at Spanish National Research Council
Publications - 44
Citations - 2965
Juan Pablo Couso is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Gene & Open reading frame. The author has an hindex of 25, co-authored 42 publications receiving 2474 citations. Previous affiliations of Juan Pablo Couso include Pablo de Olavide University & Brighton and Sussex Medical School.
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Peptides encoded by short ORFs control development and define a new eukaryotic gene family.
TL;DR: It is shown that tal controls gene expression and tissue folding in Drosophila, thus acting as a link between patterning and morphogenesis, and defines two novel paradigms in eukaryotic coding genes: the existence of short, unprocessed peptides with key biological functions, and their arrangement in polycistronic messengers.
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Conserved Regulation of Cardiac Calcium Uptake by Peptides Encoded in Small Open Reading Frames
Emile G. Magny,Jose Ignacio Pueyo,Frances M. G. Pearl,Miguel Angel Cespedes,Jeremy E. Niven,Sarah A. Bishop,Juan Pablo Couso +6 more
TL;DR: Two smORF-encoded peptides of less than 30 amino acids regulating calcium transport and, hence, regular heart contraction, in the fruit fly Drosophila heart are described, suggesting that the mechanisms for heart regulation are ancient and that smORFs may be a fundamental genome component that should be studied systematically.
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Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq
Julie L Aspden,Ying Chen Eyre-Walker,Rose J Phillips,Unum Amin,Muhammad Ali Shahzad Mumtaz,Michele Brocard,Juan Pablo Couso +6 more
TL;DR: This study presents a genome-wide assessment of smORF translation by ribosomal profiling of polysomal fractions in Drosophila, and indicates that thousands of sm ORFs are translated in metazoan genomes, reinforcing the idea that smORFs are an abundant and fundamental genome component.
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Discovery and Characterization of smORF-Encoded Bioactive Polypeptides
TL;DR: An overview of this emerging field of smORFs is provided and the opportunities for chemical biology to answer fundamental questions about these novel genes are highlighted to provide new insights into the protein-coding potential of genomes and identify functional genes with roles in biology and disease.
Journal ArticleDOI
Classification and function of small open reading frames
Juan Pablo Couso,Pedro Patraquim +1 more
TL;DR: This analysis introduces a distinction between different peptide-coding classes of smORFs in animal genomes, and highlights the role of model organisms for the study of small peptide biology in the context of development, physiology and human disease.