J
Juana M. Pasquini
Researcher at University of Buenos Aires
Publications - 119
Citations - 3965
Juana M. Pasquini is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Myelin & Oligodendrocyte. The author has an hindex of 30, co-authored 113 publications receiving 3619 citations. Previous affiliations of Juana M. Pasquini include National Scientific and Technical Research Council.
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Journal ArticleDOI
Oligodendrocytes and myelination: the role of iron.
TL;DR: This review gives a comprehensive overview of the existing literature on role of iron in oligodendrocytes and the mechanisms of iron acquisition and intracellular handling to identify effective therapies for dysmyelinating disorders.
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Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models.
E. Ortiz,Juana M. Pasquini,Khristy J. Thompson,Barbara T. Felt,G. Butkus,John L. Beard,James R. Connor +6 more
TL;DR: Overall, the results of this study demonstrate how myelin composition can be affected by loss of iron homeostasis and reveal specific chronic changes inMyelin composition that may affect behavior and attempts to rescue myelin deficits.
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Defective ubiquitination of cerebral proteins in Alzheimer's disease
TL;DR: The results suggest that a failure in the ubiquitination enzymatic system in brain cytosol may contribute to fibrillar pathology in AD.
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The Neurotoxic Effect of Cuprizone on Oligodendrocytes Depends on the Presence of Pro-inflammatory Cytokines Secreted by Microglia
Laura A. Pasquini,C.A. Calatayud,A.L. Bertone Uña,Violeta Millet,Juana M. Pasquini,Eduardo F. Soto +5 more
TL;DR: It is suggested that microglial cells appear to have a very active role in cuprizone-induced oligodendroglial cell death and demyelination, through the production and secretion of pro-inflammatory cytokines.
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Staufen Recruitment into Stress Granules Does Not Affect Early mRNA Transport in Oligodendrocytes
Maria Gabriela Thomas,Leandro Julián Martínez Tosar,Mariela Loschi,Juana M. Pasquini,Jorge Correale,Stefan Kindler,Graciela Lidia Boccaccio +6 more
TL;DR: It is suggested that Staufen RNPs are involved in repositioning of most polysomal mRNAs, but not of recently synthesized transcripts, during the stress response.