Juerg R. Straubhaar

TL;DR: In this article, the effects of rosiglitazone on the morphological features and protein profiles of mitochondria in 3T3-L1 adipocytes were examined.

TL;DR: Cidea and other lipid droplet proteins define a novel, highly regulated pathway of triglyceride deposition in human WAT, and support a model whereby failure of this pathway results in ectopic lipid accumulation, insulin resistance, and its associated comorbidities in humans.

TL;DR: It is implied that subcutaneous adipose tissue has a higher capacity to expand its capillary network than visceral tissue, but this capacity decreases with morbid obesity, and the decrease correlates with insulin resistance, suggesting that impairment of sub cutaneous adiposes tissue angiogenesis may contribute to metabolic disease pathogenesis.

TL;DR: Five allele- specific siRNAs, corresponding to just three SNP sites, could be used to treat three-quarters of the United States and European HD patient populations, laying the foundation for allele-specific RNA interference (RNAi) therapy for HD.

TL;DR: In this article, perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome.