T
Timothy P. Fitzgibbons
Researcher at University of Massachusetts Medical School
Publications - 62
Citations - 2187
Timothy P. Fitzgibbons is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Adipose tissue & Heart failure. The author has an hindex of 17, co-authored 52 publications receiving 1629 citations. Previous affiliations of Timothy P. Fitzgibbons include Boston University & Harvard University.
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Journal ArticleDOI
IRF3 and type I interferons fuel a fatal response to myocardial infarction.
Kevin R. King,Aaron D. Aguirre,Yu-Xiang Ye,Yuan Sun,Jason D. Roh,Richard P. Ng,Rainer H. Kohler,Sean P. Arlauckas,Yoshiko Iwamoto,Andrej J. Savol,Ruslan I. Sadreyev,Mark J. S. Kelly,Timothy P. Fitzgibbons,Katherine A. Fitzgerald,Timothy J. Mitchison,Peter Libby,Matthias Nahrendorf,Ralph Weissleder +17 more
TL;DR: It is shown that ischemic cell death and uptake of cell debris by macrophages in the heart fuel a fatal response to MI by activating IRF3 and type I IFN production.
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Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation
Timothy P. Fitzgibbons,Sophia Kogan,Myriam Aouadi,Gregory M. Hendricks,Juerg R. Straubhaar,Michael P. Czech +5 more
TL;DR: In this article, perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome.
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Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice
So Yun Min,Jamie Kady,Minwoo Nam,Raziel Rojas-Rodriguez,Aaron Berkenwald,Jong Hun Kim,Hye Lim Noh,Jason K. Kim,Marcus P. Cooper,Timothy P. Fitzgibbons,Michael A. Brehm,Silvia Corvera +11 more
TL;DR: It is reported that human brite/beige adipocyte progenitors proliferate in response to pro-angiogenic factors, in association with expanding capillary networks, and activated beige/brite adipocytes can affect systemic glucose homeostasis, potentially through a neuroendocrine mechanism.
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Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations.
TL;DR: It is well established that the cardiovascular risk of obesity is more strongly associated with visceral rather than subcutaneous adiposity, and Anthropometric variables that account for visceral adiposity have limited influence on this risk.
Journal ArticleDOI
Acquired long QT syndrome from stress cardiomyopathy is associated with ventricular arrhythmias and torsades de pointes.
Christopher Madias,Timothy P. Fitzgibbons,Alawi A. Alsheikh-Ali,Joseph L. Bouchard,Benjamin Kalsmith,Ann C. Garlitski,Dennis A. Tighe,N.A. Mark Estes,Gerard P. Aurigemma,Mark S. Link +9 more
TL;DR: Assessment of the prevalence and clinical predictors of ventricular arrhythmias in a cohort of patients with stress cardiomyopathy found that SCM should be recognized among the causes of acquired long QT syndrome and can be associated with a risk of TdP.