J
Julia Y. Wang
Researcher at Brigham and Women's Hospital
Publications - 38
Citations - 1419
Julia Y. Wang is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 16, co-authored 34 publications receiving 1218 citations. Previous affiliations of Julia Y. Wang include Memorial Sloan Kettering Cancer Center.
Papers
More filters
Journal ArticleDOI
A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization.
TL;DR: The results are the basis for the discovery of small-molecule inhibitors of the protein-protein interaction between human calcineurin and NFAT transcription factors, as discussed in the subsequent paper.
Journal ArticleDOI
Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharides
TL;DR: The results provide a structure/function rationale for abscess formation by S. aureus and expand the sphere of encapsulated organisms that interact directly with T cells to regulate this host response to bacterial infection.
Journal ArticleDOI
A dually active anthrax vaccine that confers protection against both bacilli and toxins.
Gi-eun Rhie,Michael H. Roehrl,Michael Mourez,R. John Collier,John J. Mekalanos,Julia Y. Wang +5 more
TL;DR: DAAV combines both antibacterial and antitoxic components in a single vaccine against anthrax, introducing a vaccine design that may be widely applicable against infectious diseases and provides additional tools in medicine and biodefense.
Journal ArticleDOI
Glycosaminoglycans are a potential cause of rheumatoid arthritis
Julia Y. Wang,Michael H. Roehrl +1 more
TL;DR: It is shown that injection of GAGs such as hyaluronic acid, heparin, and chondroitin sulfates A, B, and C induce arthritis, tendosynovitis, dermatitis, and other pathological conditions in mice and suggests that carbohydrate self-antigenic G AGs provoke autoimmune dysfunctions that involve the expansion of G AG-binding cells which migrate to anatomical sites rich in GAGS.
Journal ArticleDOI
Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer.
TL;DR: Hparin affinity fractionation enrichment (HAFE) is described as a prefractionation tool for the study of the human primary tissue proteome and the discovery of PSB7, PRDX1, and SRP9 up-regulation as candidate biomarkers of colon cancer.